Inhibition of cell proliferation by an anti-EGFR aptamer

Aptamers continue to receive interest as potential therapeutic agents for the treatment of diseases, including cancer. In order to determine whether aptamers might eventually prove to be as useful as other clinical biopolymers, such as antibodies, we selected aptamers against an important clinical t...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e20299
Hauptverfasser:	Li, Na, Nguyen, Hong Hanh, Byrom, Michelle, Ellington, Andrew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Aptamers Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - genetics Aptamers, Nucleotide - metabolism Aptamers, Nucleotide - pharmacology Base Sequence Binding Biological Transport Biology Biopolymers Brain cancer Cancer Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chemical compounds Chemistry Clonal deletion Cloning Contrast agents Contrast media Deletion mutant Deoxyribonucleic acid DNA Epidermal growth factor Epidermal Growth Factor - metabolism Epidermal Growth Factor - pharmacology Epidermal growth factor receptors Epidermal growth factors Epitopes Gene Expression Regulation, Neoplastic - drug effects Glioblastoma Glioblastoma multiforme Health aspects Humans Kinases Ligands Lung cancer Lungs Medical treatment Molecular biology Mutation Optimization Pharmacology Phosphorylation - drug effects Physiological aspects Prostate Proteins R&D Radiation therapy Receptor, Epidermal Growth Factor - metabolism Research & development RNA polymerase Substrate Specificity Therapeutics Thymidine - analogs & derivatives Thymidine - chemistry Tumor cells Vascular endothelial growth factor
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