Nitric oxide-induced activation of the AMP-activated protein kinase α2 subunit attenuates IκB kinase activity and inflammatory responses in endothelial cells

In endothelial cells, activation of the AMP-activated protein kinase (AMPK) has been linked with anti-inflammatory actions but the events downstream of kinase activation are not well understood. Here, we addressed the effects of AMPK activation/deletion on the activation of NFκB and determined wheth...

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Veröffentlicht in:	PloS one 2011, Vol.6 (6), p.e20848
Hauptverfasser:	Bess, Elke, Fisslthaler, Beate, Frömel, Timo, Fleming, Ingrid
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation AMP AMP-activated protein kinase AMP-Activated Protein Kinases - deficiency AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Biology Biomedical research Cell Adhesion - drug effects Cercopithecus aethiops Clonal deletion COS Cells E-selectin E-Selectin - metabolism Endothelial cells Endothelial Cells - drug effects Endothelial Cells - enzymology Endothelial Cells - metabolism Endothelial Cells - pathology Enzyme Activation - drug effects Enzymes Gene Deletion Gene expression Gene Expression Regulation - drug effects Glucose Human subjects Humans Hypoglycemia I-kappa B Kinase - antagonists & inhibitors I-kappa B Kinase - metabolism IKK protein IL-1β Inflammation Inflammation - enzymology Inflammation - metabolism Inflammation - pathology Inhibition Interleukin Interleukins Kinases Leukemia Medicine Metabolism Mice Monocytes Musculoskeletal system NF-kappa B - metabolism NF-κB protein Nitric oxide Nitric Oxide - pharmacology Phosphorylation Proteins Smooth muscle Substrates Tumor necrosis factor-TNF Tumor necrosis factor-α Vascular Cell Adhesion Molecule-1 - metabolism
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