Identification of the allosteric regulatory site of insulysin

Insulin degrading enzyme (IDE) is responsible for the metabolism of insulin and plays a role in clearance of the Aβ peptide associated with Alzheimer's disease. Unlike most proteolytic enzymes, IDE, which consists of four structurally related domains and exists primarily as a dimer, exhibits al...

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Veröffentlicht in:	PLoS One 2011-06, Vol.6 (6), p.e20864-e20864
Hauptverfasser:	Noinaj, Nicholas, Bhasin, Sonia K, Song, Eun Suk, Scoggin, Kirsten E, Juliano, Maria A, Juliano, Luiz, Hersh, Louis B, Rodgers, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Activation Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - metabolism Allosteric properties Allosteric Regulation Allosteric Site Alzheimer's disease Analysis Animals Aspartic proteases ATP Automation BASIC BIOLOGICAL SCIENCES Binding sites Biochemistry Biology Biophysics Chromatography CLEARANCE COMMUNICATIONS CONFORMATIONAL CHANGES CRYSTAL STRUCTURE Crystallography, X-Ray Datasets Diabetes DIMERS ELECTRON DENSITY Enzymatic activity ENZYME ACTIVITY ENZYMES INSULIN Insulysin Insulysin - chemistry Insulysin - metabolism KINETICS Life sciences Ligands Mass Spectrometry METABOLISM Models, Molecular Mutant Proteins - chemistry Mutant Proteins - metabolism MUTANTS Mutation - genetics Neurodegenerative diseases PEPTIDES Physiological aspects Polyphosphates Protein Binding Protein Multimerization Protein Structure, Secondary Proteins Proteolysis Proteolytic enzymes Rats Reaction kinetics RESIDUES Scientific imaging Spectrometry, Fluorescence SUBSTRATES Type 2 diabetes
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