Incorporation of real-time PCR into routine public health surveillance of culture negative bacterial meningitis in São Paulo, Brazil

Real-time (RT)-PCR increases diagnostic yield for bacterial meningitis and is ideal for incorporation into routine surveillance in a developing country. We validated a multiplex RT-PCR assay for Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae in Brazil. Risk factors for...

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Veröffentlicht in:	PloS one 2011, Vol.6 (6), p.e20675-e20675
Hauptverfasser:	Sacchi, Claudio T, Fukasawa, Lucila O, Gonçalves, Maria G, Salgado, Maristela M, Shutt, Kathleen A, Carvalhanas, Telma R, Ribeiro, Ana F, Kemp, Brigina, Gorla, Maria C O, Albernaz, Ricardo K, Marques, Eneida G L, Cruciano, Angela, Waldman, Eliseu A, Brandileone, M Cristina C, Harrison, Lee H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antibiotics Antimicrobial agents Bacteria Bacterial Typing Techniques Bacteriology Biology Biosensors Brazil Cerebrospinal fluid Child Child, Preschool Confidence limits Culture Deoxyribonucleic acid Developing countries Diagnostic systems DNA DNA polymerase Drug resistance Epidemiology Female Gram-negative bacteria Health risks Health surveillance Hospitals Humans Immunology Infant Infant, Newborn Infectious diseases Laboratories LDCs Leukocyte Count Male Medicine Meningitis Meningitis, Bacterial - blood Meningitis, Bacterial - cerebrospinal fluid Meningitis, Bacterial - microbiology Middle Aged Multiplexing Multivariate Analysis Neisseria meningitidis - classification Neisseria meningitidis - genetics Pharmacists Pneumonia Polymerase chain reaction Population Surveillance - methods Public health Real time Reproducibility of Results Reverse Transcriptase Polymerase Chain Reaction - methods Risk analysis Risk Factors Sensitivity and Specificity Streptococcus infections Streptococcus pneumoniae Studies Surveillance Vaccines Young Adult
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