Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases

Highly selective, cell-permeable and fast-acting inhibitors of individual kinases are sought-after as tools for studying the cellular function of kinases in real time. A combination of small molecule synthesis and protein mutagenesis, identified a highly potent inhibitor (1-Isopropyl-3-(phenylethyny...

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Veröffentlicht in:	PloS one 2011, Vol.6 (6), p.e20789
Hauptverfasser:	Klein, Michael, Morillas, Montse, Vendrell, Alexandre, Brive, Lars, Gebbia, Marinella, Wallace, Iain M, Giaever, Guri, Nislow, Corey, Posas, Francesc, Grøtli, Morten
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Andra medicinska och farmaceutiska grundvetenskaper Bioinformatics Biology Cell Cycle Chemical Sciences Chemical synthesis Chemistry Drug Design Drug dosages Enzyme inhibitors Gene Expression Genomes Genètica Hog1 protein Inhibitors Inhibitory Concentration 50 Kemi Kinases Magnetic Resonance Spectroscopy Mutagenesis Other Basic Medicine Pharmaceutical sciences Phosphotransferases Protein biosynthesis Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein-serine/threonine kinase Proteins Proteïnes quinases Selectivity Signal transduction Signaling Technology assessment Threonine Yeast Yeasts
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