Modulation of myocardial mitochondrial mechanisms during severe polymicrobial sepsis in the rat

We tested the hypothesis that 5-Hydroxydecanoic acid (5HD), a putative mitoK(ATP) channel blocker, will reverse sepsis-induced cardiodynamic and adult rat ventricular myocyte (ARVM) contractile dysfunction, restore mitochondrial membrane permeability alterations and improve survival. Male Sprague-Da...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e21285-e21285
Hauptverfasser:	Chopra, Mani, Golden, Honey B, Mullapudi, Srinivas, Dowhan, William, Dostal, David E, Sharma, Avadhesh C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anion channels Anti-Arrhythmia Agents - pharmacology Apoptosis Bax protein bcl-2-Associated X Protein - metabolism Biochemistry Biology Body Temperature - drug effects Cardiac output Cardiology Cecum Channels Contractility Cytochrome Cytochrome c Cytochromes c - metabolism Decanoic Acids - metabolism Decanoic Acids - pharmacology Dentistry Dextrose EKG Electrocardiography Heart Heart diseases Hemodynamics High definition television Hydroxy Acids - metabolism Hydroxy Acids - pharmacology Infection Infusion Inoculum Kinases Laboratories Male Medicine Membrane permeability Membrane potential Membrane Potential, Mitochondrial - drug effects Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - ultrastructure Molecular biology Mortality Muscle contraction Myocardial Contraction - drug effects Myocardium - cytology Myocardium - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Norepinephrine Permeability Potassium Channel Blockers - metabolism Potassium Channel Blockers - pharmacology Potassium Channels - metabolism Pretreatment Proteins Random Allocation Rats Rats, Sprague-Dawley Rodents Science Sepsis Sepsis - microbiology Sepsis - mortality Sepsis - physiopathology Tumor Necrosis Factor-alpha - metabolism Ultrasonic imaging Ventricle Voltage-Dependent Anion Channel 1 - metabolism
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