OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62

We earlier identified OSBP-related protein 8 (ORP8) as an endoplasmic reticulum oxysterol-binding protein implicated in cellular lipid homeostasis. We now investigated its action in hepatic cells in vivo and in vitro. Adenoviral overexpression of ORP8 in mouse liver induced a decrease of cholesterol...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e21078-e21078
Hauptverfasser:	Zhou, Tianhong, Li, Shiqian, Zhong, Wenbin, Vihervaara, Terhi, Béaslas, Olivier, Perttilä, Julia, Luo, Wei, Jiang, Yingliang, Lehto, Markku, Olkkonen, Vesa M, Yan, Daoguang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Adenoviruses Analysis Animals Base Sequence Biology Biosynthesis Cell Line, Tumor Cholesterol Cloning Complementation DNA Primers Endoplasmic reticulum Female Fluorescence Gene expression Genes Homeostasis Humans Immunofluorescence Immunoprecipitation In vivo methods and tests Kinases Laboratory animals Lipid Metabolism Lipids Lipids - blood Liver Liver - metabolism Localization Medical research Medical screening Membrane Glycoproteins - metabolism Metabolism Mice Mice, Inbred C57BL Microscopy Microscopy, Fluorescence mRNA Nuclear Pore Complex Proteins - metabolism Phospholipids Physiological aspects Plasma Porins Protein Binding Proteins Receptors, Steroid - metabolism Receptors, Steroid - physiology Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA-mediated interference Sterol regulatory element-binding protein Sterols Transcription factors Triglycerides Two-Hybrid System Techniques Yeast
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