Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-Fluorouracil
Concurrent chemoradiation with 5-fluorouracil (5-FU) is widely accepted for cancer treatment. However, the interactions between radiation and 5-FU remain unclear. Here, we evaluated the influence of local irradiation on the pharmacokinetics of 5-FU in rats. The single-fraction radiation was delivere...
Gespeichert in:
| Veröffentlicht in: | PloS one 2011-06, Vol.6 (6), p.e21000 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 6 |
| container_start_page | e21000 |
| container_title | PloS one |
| container_volume | 6 |
| creator | Hsieh, Chen-Hsi Liu, Chia-Yuan Hsieh, Yen-Ju Tai, Hung-Chi Wang, Li-Ying Tsai, Tung-Hu Chen, Yu-Jen |
| description | Concurrent chemoradiation with 5-fluorouracil (5-FU) is widely accepted for cancer treatment. However, the interactions between radiation and 5-FU remain unclear. Here, we evaluated the influence of local irradiation on the pharmacokinetics of 5-FU in rats. The single-fraction radiation was delivered to the whole pelvic fields of Sprague-Dawley rats after computerized tomography-based planning. 5-FU at 100 mg/kg was prescribed 24 hours after radiation. A high-performance liquid chromatography system was used to measure 5-FU in the blood. Matrix metalloproteinase-8 (MMP-8) inhibitor I was administered to examine whether or not RT modulation of 5-FU pharmacokinetic parameters could be blocked. Compared with sham-irradiated controls, whole pelvic irradiation reduced the area under the concentration versus time curve (AUC) of 5-FU in plasma and, in contrast, increased in bile with a radiation dose-dependent manner. Based on protein array analysis, the amount of plasma MMP-8 was increased by whole pelvic irradiation (2.8-fold by 0.5 Gy and 5.3-fold by 2 Gy) in comparison with controls. Pretreatment with MMP-8 inhibitor reversed the effect of irradiation on AUC of 5-FU in plasma. Our findings first indicate that local irradiation modulate the systemic pharmacokinetics of 5-FU through stimulating the release of MMP-8. The pharmacokinetics of 5-FU during concurrent chemoradiaiton therapy should be rechecked and the optimal 5-FU dose should be reevaluated, and adjusted if necessary, during CCRT. |
| doi_str_mv | 10.1371/journal.pone.0021000 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1304770774</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A476888321</galeid><doaj_id>oai_doaj_org_article_e2c14446037048a8a33b114b811d1838</doaj_id><sourcerecordid>A476888321</sourcerecordid><originalsourceid>FETCH-LOGICAL-c691t-d20b6115544c571a85df044bddd0d08034baaca79557bd26a6551765381e51633</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7rr6D0QLguJFx6T5nBthWVwdWFnw6zacpulMxkwzJumy-yv8y6ZOd5mRvZAWWk6f903fk5yieI7RDBOB3639EHpws63vzQyhGiOEHhTHeE7qiteIPNx7PyqexLhGiBHJ-ePiqMZ8zmpOj4vfnyEFe11uTALn_Db4ZGwP0VQy11oLycQyrUw59B1c-QCNM2W8iclsrC7tZgs6lb4rndfgShsCjBrr-zLf2xWEDWj_0_YmWR1HEPpkKw29NqFsw7AsWXXuBh9yGtDWPS0edeCieTY9T4rv5x--nX2qLi4_Ls5OLyrN5zhVbY0ajjFjlGomMEjWdojSpm1b1CKJCG0ANIg5Y6Jpaw6cMSx4zo8Nw5yQk-LlznfrfFRTL6PCBFEhkBA0E4sd0XpYq22wGwg3yoNVfws-LBWEnMoZZWqNKaUcEYGoBAmENBjTRmLcYklk9no_rTY0uava9CmAOzA9_NLblVr6K0Vw9mEsG7yZDIL_NZiY1MZGbZyD3vghKikIndNajMFe_UPeH26ilpD_3_adz8vq0VOdUsGllKTGmZrdQ-WrHXc_n7vO5vqB4O2BIDPJXKclDDGqxdcv_89e_jhkX--xKwMuraJ3w3jQ4iFId6AOPsZgurseY6TGsbnthhrHRk1jk2Uv9vfnTnQ7J-QPXWsTNw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1304770774</pqid></control><display><type>article</type><title>Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-Fluorouracil</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS)</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Hsieh, Chen-Hsi ; Liu, Chia-Yuan ; Hsieh, Yen-Ju ; Tai, Hung-Chi ; Wang, Li-Ying ; Tsai, Tung-Hu ; Chen, Yu-Jen</creator><contributor>Algül, Hana</contributor><creatorcontrib>Hsieh, Chen-Hsi ; Liu, Chia-Yuan ; Hsieh, Yen-Ju ; Tai, Hung-Chi ; Wang, Li-Ying ; Tsai, Tung-Hu ; Chen, Yu-Jen ; Algül, Hana</creatorcontrib><description>Concurrent chemoradiation with 5-fluorouracil (5-FU) is widely accepted for cancer treatment. However, the interactions between radiation and 5-FU remain unclear. Here, we evaluated the influence of local irradiation on the pharmacokinetics of 5-FU in rats. The single-fraction radiation was delivered to the whole pelvic fields of Sprague-Dawley rats after computerized tomography-based planning. 5-FU at 100 mg/kg was prescribed 24 hours after radiation. A high-performance liquid chromatography system was used to measure 5-FU in the blood. Matrix metalloproteinase-8 (MMP-8) inhibitor I was administered to examine whether or not RT modulation of 5-FU pharmacokinetic parameters could be blocked. Compared with sham-irradiated controls, whole pelvic irradiation reduced the area under the concentration versus time curve (AUC) of 5-FU in plasma and, in contrast, increased in bile with a radiation dose-dependent manner. Based on protein array analysis, the amount of plasma MMP-8 was increased by whole pelvic irradiation (2.8-fold by 0.5 Gy and 5.3-fold by 2 Gy) in comparison with controls. Pretreatment with MMP-8 inhibitor reversed the effect of irradiation on AUC of 5-FU in plasma. Our findings first indicate that local irradiation modulate the systemic pharmacokinetics of 5-FU through stimulating the release of MMP-8. The pharmacokinetics of 5-FU during concurrent chemoradiaiton therapy should be rechecked and the optimal 5-FU dose should be reevaluated, and adjusted if necessary, during CCRT.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0021000</identifier><identifier>PMID: 21695264</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>5-Fluorouracil ; Animals ; Antineoplastic Agents - blood ; Antineoplastic Agents - pharmacokinetics ; Antineoplastic Agents - pharmacology ; Atherosclerosis ; Bile ; Bile - drug effects ; Bile - metabolism ; Bile - radiation effects ; Cancer ; Cancer therapies ; Chemoradiotherapy ; Chemotherapy ; Chemotherapy, Adjuvant ; Chromatography ; Clinical medicine ; Colorectal cancer ; Comparative analysis ; Computed tomography ; Cytokines ; Cytokines - metabolism ; Dehydrogenases ; Drug dosages ; Enzyme Inhibitors - pharmacology ; Fluorouracil ; Fluorouracil - blood ; Fluorouracil - pharmacokinetics ; Fluorouracil - pharmacology ; Head & neck cancer ; Hemodialysis ; High performance liquid chromatography ; Hospitals ; Inhibitors ; Intracellular Space - drug effects ; Intracellular Space - metabolism ; Intracellular Space - radiation effects ; Irradiation ; Liquid chromatography ; Liver - drug effects ; Liver - physiology ; Liver - radiation effects ; Male ; Matrix metalloproteinase ; Matrix Metalloproteinase 8 - metabolism ; Matrix Metalloproteinase Inhibitors ; Medicine ; Metabolism ; Metabolites ; Metalloproteinase ; Neutrophil collagenase ; Oncology ; Patients ; Pelvis - radiation effects ; Pharmacokinetics ; Pharmacology ; Plasma ; Pretreatment ; Protein arrays ; Radiation ; Radiation (Physics) ; Radiation dosage ; Radiation therapy ; Rats ; Rats, Sprague-Dawley ; Rodents ; Solubility ; Tumor necrosis factor-TNF</subject><ispartof>PloS one, 2011-06, Vol.6 (6), p.e21000</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Hsieh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Hsieh et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-d20b6115544c571a85df044bddd0d08034baaca79557bd26a6551765381e51633</citedby><cites>FETCH-LOGICAL-c691t-d20b6115544c571a85df044bddd0d08034baaca79557bd26a6551765381e51633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111455/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111455/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21695264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Algül, Hana</contributor><creatorcontrib>Hsieh, Chen-Hsi</creatorcontrib><creatorcontrib>Liu, Chia-Yuan</creatorcontrib><creatorcontrib>Hsieh, Yen-Ju</creatorcontrib><creatorcontrib>Tai, Hung-Chi</creatorcontrib><creatorcontrib>Wang, Li-Ying</creatorcontrib><creatorcontrib>Tsai, Tung-Hu</creatorcontrib><creatorcontrib>Chen, Yu-Jen</creatorcontrib><title>Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-Fluorouracil</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Concurrent chemoradiation with 5-fluorouracil (5-FU) is widely accepted for cancer treatment. However, the interactions between radiation and 5-FU remain unclear. Here, we evaluated the influence of local irradiation on the pharmacokinetics of 5-FU in rats. The single-fraction radiation was delivered to the whole pelvic fields of Sprague-Dawley rats after computerized tomography-based planning. 5-FU at 100 mg/kg was prescribed 24 hours after radiation. A high-performance liquid chromatography system was used to measure 5-FU in the blood. Matrix metalloproteinase-8 (MMP-8) inhibitor I was administered to examine whether or not RT modulation of 5-FU pharmacokinetic parameters could be blocked. Compared with sham-irradiated controls, whole pelvic irradiation reduced the area under the concentration versus time curve (AUC) of 5-FU in plasma and, in contrast, increased in bile with a radiation dose-dependent manner. Based on protein array analysis, the amount of plasma MMP-8 was increased by whole pelvic irradiation (2.8-fold by 0.5 Gy and 5.3-fold by 2 Gy) in comparison with controls. Pretreatment with MMP-8 inhibitor reversed the effect of irradiation on AUC of 5-FU in plasma. Our findings first indicate that local irradiation modulate the systemic pharmacokinetics of 5-FU through stimulating the release of MMP-8. The pharmacokinetics of 5-FU during concurrent chemoradiaiton therapy should be rechecked and the optimal 5-FU dose should be reevaluated, and adjusted if necessary, during CCRT.</description><subject>5-Fluorouracil</subject><subject>Animals</subject><subject>Antineoplastic Agents - blood</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Atherosclerosis</subject><subject>Bile</subject><subject>Bile - drug effects</subject><subject>Bile - metabolism</subject><subject>Bile - radiation effects</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Chemoradiotherapy</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Chromatography</subject><subject>Clinical medicine</subject><subject>Colorectal cancer</subject><subject>Comparative analysis</subject><subject>Computed tomography</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Dehydrogenases</subject><subject>Drug dosages</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fluorouracil</subject><subject>Fluorouracil - blood</subject><subject>Fluorouracil - pharmacokinetics</subject><subject>Fluorouracil - pharmacology</subject><subject>Head & neck cancer</subject><subject>Hemodialysis</subject><subject>High performance liquid chromatography</subject><subject>Hospitals</subject><subject>Inhibitors</subject><subject>Intracellular Space - drug effects</subject><subject>Intracellular Space - metabolism</subject><subject>Intracellular Space - radiation effects</subject><subject>Irradiation</subject><subject>Liquid chromatography</subject><subject>Liver - drug effects</subject><subject>Liver - physiology</subject><subject>Liver - radiation effects</subject><subject>Male</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 8 - metabolism</subject><subject>Matrix Metalloproteinase Inhibitors</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metalloproteinase</subject><subject>Neutrophil collagenase</subject><subject>Oncology</subject><subject>Patients</subject><subject>Pelvis - radiation effects</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><subject>Plasma</subject><subject>Pretreatment</subject><subject>Protein arrays</subject><subject>Radiation</subject><subject>Radiation (Physics)</subject><subject>Radiation dosage</subject><subject>Radiation therapy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Solubility</subject><subject>Tumor necrosis factor-TNF</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLguJFx6T5nBthWVwdWFnw6zacpulMxkwzJumy-yv8y6ZOd5mRvZAWWk6f903fk5yieI7RDBOB3639EHpws63vzQyhGiOEHhTHeE7qiteIPNx7PyqexLhGiBHJ-ePiqMZ8zmpOj4vfnyEFe11uTALn_Db4ZGwP0VQy11oLycQyrUw59B1c-QCNM2W8iclsrC7tZgs6lb4rndfgShsCjBrr-zLf2xWEDWj_0_YmWR1HEPpkKw29NqFsw7AsWXXuBh9yGtDWPS0edeCieTY9T4rv5x--nX2qLi4_Ls5OLyrN5zhVbY0ajjFjlGomMEjWdojSpm1b1CKJCG0ANIg5Y6Jpaw6cMSx4zo8Nw5yQk-LlznfrfFRTL6PCBFEhkBA0E4sd0XpYq22wGwg3yoNVfws-LBWEnMoZZWqNKaUcEYGoBAmENBjTRmLcYklk9no_rTY0uava9CmAOzA9_NLblVr6K0Vw9mEsG7yZDIL_NZiY1MZGbZyD3vghKikIndNajMFe_UPeH26ilpD_3_adz8vq0VOdUsGllKTGmZrdQ-WrHXc_n7vO5vqB4O2BIDPJXKclDDGqxdcv_89e_jhkX--xKwMuraJ3w3jQ4iFId6AOPsZgurseY6TGsbnthhrHRk1jk2Uv9vfnTnQ7J-QPXWsTNw</recordid><startdate>20110609</startdate><enddate>20110609</enddate><creator>Hsieh, Chen-Hsi</creator><creator>Liu, Chia-Yuan</creator><creator>Hsieh, Yen-Ju</creator><creator>Tai, Hung-Chi</creator><creator>Wang, Li-Ying</creator><creator>Tsai, Tung-Hu</creator><creator>Chen, Yu-Jen</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110609</creationdate><title>Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-Fluorouracil</title><author>Hsieh, Chen-Hsi ; Liu, Chia-Yuan ; Hsieh, Yen-Ju ; Tai, Hung-Chi ; Wang, Li-Ying ; Tsai, Tung-Hu ; Chen, Yu-Jen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-d20b6115544c571a85df044bddd0d08034baaca79557bd26a6551765381e51633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>5-Fluorouracil</topic><topic>Animals</topic><topic>Antineoplastic Agents - blood</topic><topic>Antineoplastic Agents - pharmacokinetics</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Atherosclerosis</topic><topic>Bile</topic><topic>Bile - drug effects</topic><topic>Bile - metabolism</topic><topic>Bile - radiation effects</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Chemoradiotherapy</topic><topic>Chemotherapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Chromatography</topic><topic>Clinical medicine</topic><topic>Colorectal cancer</topic><topic>Comparative analysis</topic><topic>Computed tomography</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Dehydrogenases</topic><topic>Drug dosages</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fluorouracil</topic><topic>Fluorouracil - blood</topic><topic>Fluorouracil - pharmacokinetics</topic><topic>Fluorouracil - pharmacology</topic><topic>Head & neck cancer</topic><topic>Hemodialysis</topic><topic>High performance liquid chromatography</topic><topic>Hospitals</topic><topic>Inhibitors</topic><topic>Intracellular Space - drug effects</topic><topic>Intracellular Space - metabolism</topic><topic>Intracellular Space - radiation effects</topic><topic>Irradiation</topic><topic>Liquid chromatography</topic><topic>Liver - drug effects</topic><topic>Liver - physiology</topic><topic>Liver - radiation effects</topic><topic>Male</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 8 - metabolism</topic><topic>Matrix Metalloproteinase Inhibitors</topic><topic>Medicine</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metalloproteinase</topic><topic>Neutrophil collagenase</topic><topic>Oncology</topic><topic>Patients</topic><topic>Pelvis - radiation effects</topic><topic>Pharmacokinetics</topic><topic>Pharmacology</topic><topic>Plasma</topic><topic>Pretreatment</topic><topic>Protein arrays</topic><topic>Radiation</topic><topic>Radiation (Physics)</topic><topic>Radiation dosage</topic><topic>Radiation therapy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Solubility</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsieh, Chen-Hsi</creatorcontrib><creatorcontrib>Liu, Chia-Yuan</creatorcontrib><creatorcontrib>Hsieh, Yen-Ju</creatorcontrib><creatorcontrib>Tai, Hung-Chi</creatorcontrib><creatorcontrib>Wang, Li-Ying</creatorcontrib><creatorcontrib>Tsai, Tung-Hu</creatorcontrib><creatorcontrib>Chen, Yu-Jen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsieh, Chen-Hsi</au><au>Liu, Chia-Yuan</au><au>Hsieh, Yen-Ju</au><au>Tai, Hung-Chi</au><au>Wang, Li-Ying</au><au>Tsai, Tung-Hu</au><au>Chen, Yu-Jen</au><au>Algül, Hana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-Fluorouracil</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-06-09</date><risdate>2011</risdate><volume>6</volume><issue>6</issue><spage>e21000</spage><pages>e21000-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Concurrent chemoradiation with 5-fluorouracil (5-FU) is widely accepted for cancer treatment. However, the interactions between radiation and 5-FU remain unclear. Here, we evaluated the influence of local irradiation on the pharmacokinetics of 5-FU in rats. The single-fraction radiation was delivered to the whole pelvic fields of Sprague-Dawley rats after computerized tomography-based planning. 5-FU at 100 mg/kg was prescribed 24 hours after radiation. A high-performance liquid chromatography system was used to measure 5-FU in the blood. Matrix metalloproteinase-8 (MMP-8) inhibitor I was administered to examine whether or not RT modulation of 5-FU pharmacokinetic parameters could be blocked. Compared with sham-irradiated controls, whole pelvic irradiation reduced the area under the concentration versus time curve (AUC) of 5-FU in plasma and, in contrast, increased in bile with a radiation dose-dependent manner. Based on protein array analysis, the amount of plasma MMP-8 was increased by whole pelvic irradiation (2.8-fold by 0.5 Gy and 5.3-fold by 2 Gy) in comparison with controls. Pretreatment with MMP-8 inhibitor reversed the effect of irradiation on AUC of 5-FU in plasma. Our findings first indicate that local irradiation modulate the systemic pharmacokinetics of 5-FU through stimulating the release of MMP-8. The pharmacokinetics of 5-FU during concurrent chemoradiaiton therapy should be rechecked and the optimal 5-FU dose should be reevaluated, and adjusted if necessary, during CCRT.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21695264</pmid><doi>10.1371/journal.pone.0021000</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2011-06, Vol.6 (6), p.e21000 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1304770774 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 5-Fluorouracil Animals Antineoplastic Agents - blood Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Atherosclerosis Bile Bile - drug effects Bile - metabolism Bile - radiation effects Cancer Cancer therapies Chemoradiotherapy Chemotherapy Chemotherapy, Adjuvant Chromatography Clinical medicine Colorectal cancer Comparative analysis Computed tomography Cytokines Cytokines - metabolism Dehydrogenases Drug dosages Enzyme Inhibitors - pharmacology Fluorouracil Fluorouracil - blood Fluorouracil - pharmacokinetics Fluorouracil - pharmacology Head & neck cancer Hemodialysis High performance liquid chromatography Hospitals Inhibitors Intracellular Space - drug effects Intracellular Space - metabolism Intracellular Space - radiation effects Irradiation Liquid chromatography Liver - drug effects Liver - physiology Liver - radiation effects Male Matrix metalloproteinase Matrix Metalloproteinase 8 - metabolism Matrix Metalloproteinase Inhibitors Medicine Metabolism Metabolites Metalloproteinase Neutrophil collagenase Oncology Patients Pelvis - radiation effects Pharmacokinetics Pharmacology Plasma Pretreatment Protein arrays Radiation Radiation (Physics) Radiation dosage Radiation therapy Rats Rats, Sprague-Dawley Rodents Solubility Tumor necrosis factor-TNF |
| title | Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-Fluorouracil |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T20%3A50%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Matrix%20metalloproteinase-8%20mediates%20the%20unfavorable%20systemic%20impact%20of%20local%20irradiation%20on%20pharmacokinetics%20of%20anti-cancer%20drug%205-Fluorouracil&rft.jtitle=PloS%20one&rft.au=Hsieh,%20Chen-Hsi&rft.date=2011-06-09&rft.volume=6&rft.issue=6&rft.spage=e21000&rft.pages=e21000-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0021000&rft_dat=%3Cgale_plos_%3EA476888321%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1304770774&rft_id=info:pmid/21695264&rft_galeid=A476888321&rft_doaj_id=oai_doaj_org_article_e2c14446037048a8a33b114b811d1838&rfr_iscdi=true |