Beta-carotene reduces body adiposity of mice via BCMO1

Evidence from cell culture studies indicates that β-carotene-(BC)-derived apocarotenoid signaling molecules can modulate the activities of nuclear receptors that regulate many aspects of adipocyte physiology. Two BC metabolizing enzymes, the BC-15,15'-oxygenase (Bcmo1) and the BC-9',10...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e20644
Hauptverfasser:	Amengual, Jaume, Gouranton, Erwan, van Helden, Yvonne G J, Hessel, Susanne, Ribot, Joan, Kramer, Evelien, Kiec-Wilk, Beata, Razny, Ursula, Lietz, Georg, Wyss, Adrian, Dembinska-Kiec, Aldona, Palou, Andreu, Keijer, Jaap, Landrier, Jean François, Bonet, M Luisa, von Lintig, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes, White - drug effects Adipocytes, White - metabolism Adipose tissue Adiposity - drug effects Animals Beta carotene beta Carotene - pharmacology beta-Carotene 15,15'-Monooxygenase - genetics beta-Carotene 15,15'-Monooxygenase - metabolism Biochemistry Biology Biopsy Biotechnology Carotenoids Cell culture Diabetes diabetes-mellitus Diet Dietary Supplements Dioxygenases DNA microarrays Down-Regulation - drug effects Enzymes Female Food safety Gene expression Genes Genomes Genomics Impact analysis Influence Ionone Laboratories leptin expression Life Sciences Lipogenesis Mammals Medicine Metabolism metabolizing enzyme Mice Mice, Inbred C57BL Molecular biology Nuclear receptors Nutrition research Obesity Oxygenase Oxygenases - genetics Oxygenases - metabolism Physiological aspects Physiology PPAR gamma - genetics PPAR gamma - metabolism ppar-gamma proliferator-activated receptors Receptors Retinaldehyde Retinoids Retinoids - blood Retinoids - metabolism Rodents serum carotenoids Signaling trans-retinoic acid Transcription (Genetics) Transcription factors User interface Vitamin A vitamin-a production β-Carotene
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