Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice
Alterations in the composition of gut microbiota--known as dysbiosis--has been proposed to contribute to the development of obesity, thereby supporting the potential interest of nutrients targeting the gut with beneficial effect for host adiposity. We test the ability of a specific concentrate of wa...
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| Veröffentlicht in: | PloS one 2011-06, Vol.6 (6), p.e20944 |
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| creator | Neyrinck, Audrey M Possemiers, Sam Druart, Céline Van de Wiele, Tom De Backer, Fabienne Cani, Patrice D Larondelle, Yvan Delzenne, Nathalie M |
| description | Alterations in the composition of gut microbiota--known as dysbiosis--has been proposed to contribute to the development of obesity, thereby supporting the potential interest of nutrients targeting the gut with beneficial effect for host adiposity. We test the ability of a specific concentrate of water-extractable high molecular weight arabinoxylans (AX) from wheat to modulate both the gut microbiota and lipid metabolism in high-fat (HF) diet-induced obese mice.
Mice were fed either a control diet (CT) or a HF diet, or a HF diet supplemented with AX (10% w/w) during 4 weeks. AX supplementation restored the number of bacteria that were decreased upon HF feeding, i.e. Bacteroides-Prevotella spp. and Roseburia spp. Importantly, AX treatment markedly increased caecal bifidobacteria content, in particular Bifidobacterium animalis lactis. This effect was accompanied by improvement of gut barrier function and by a lower circulating inflammatory marker. Interestingly, rumenic acid (C18:2 c9,t11) was increased in white adipose tissue due to AX treatment, suggesting the influence of gut bacterial metabolism on host tissue. In parallel, AX treatment decreased adipocyte size and HF diet-induced expression of genes mediating differentiation, fatty acid uptake, fatty acid oxidation and inflammation, and decreased a key lipogenic enzyme activity in the subcutaneous adipose tissue. Furthermore, AX treatment significantly decreased HF-induced adiposity, body weight gain, serum and hepatic cholesterol accumulation and insulin resistance. Correlation analysis reveals that Roseburia spp. and Bacteroides/Prevotella levels inversely correlate with these host metabolic parameters.
Supplementation of a concentrate of water-extractable high molecular weight AX in the diet counteracted HF-induced gut dysbiosis together with an improvement of obesity and lipid-lowering effects. We postulate that hypocholesterolemic, anti-inflammatory and anti-obesity effects are related to changes in gut microbiota. These data support a role for wheat AX as interesting nutrients with prebiotic properties related to obesity prevention. |
| doi_str_mv | 10.1371/journal.pone.0020944 |
| format | Article |
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Mice were fed either a control diet (CT) or a HF diet, or a HF diet supplemented with AX (10% w/w) during 4 weeks. AX supplementation restored the number of bacteria that were decreased upon HF feeding, i.e. Bacteroides-Prevotella spp. and Roseburia spp. Importantly, AX treatment markedly increased caecal bifidobacteria content, in particular Bifidobacterium animalis lactis. This effect was accompanied by improvement of gut barrier function and by a lower circulating inflammatory marker. Interestingly, rumenic acid (C18:2 c9,t11) was increased in white adipose tissue due to AX treatment, suggesting the influence of gut bacterial metabolism on host tissue. In parallel, AX treatment decreased adipocyte size and HF diet-induced expression of genes mediating differentiation, fatty acid uptake, fatty acid oxidation and inflammation, and decreased a key lipogenic enzyme activity in the subcutaneous adipose tissue. Furthermore, AX treatment significantly decreased HF-induced adiposity, body weight gain, serum and hepatic cholesterol accumulation and insulin resistance. Correlation analysis reveals that Roseburia spp. and Bacteroides/Prevotella levels inversely correlate with these host metabolic parameters.
Supplementation of a concentrate of water-extractable high molecular weight AX in the diet counteracted HF-induced gut dysbiosis together with an improvement of obesity and lipid-lowering effects. We postulate that hypocholesterolemic, anti-inflammatory and anti-obesity effects are related to changes in gut microbiota. These data support a role for wheat AX as interesting nutrients with prebiotic properties related to obesity prevention.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0020944</identifier><identifier>PMID: 21695273</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adipose tissue ; Agriculture ; Analysis ; Animals ; Arabinoxylans ; Bacteria ; Bacterial Load - drug effects ; Bacteroides - physiology ; Bifidobacterium - physiology ; Biology ; Biomarkers - metabolism ; Body weight ; Body Weight - drug effects ; Body weight gain ; Carbohydrates ; Chemistry ; Cholesterol ; Cholesterol - blood ; Colon ; Correlation analysis ; Diet ; Diet - adverse effects ; Dietary Fats - adverse effects ; Dysbacteriosis ; Ecology ; Enzymatic activity ; Enzyme activity ; Fat metabolism ; Fatty acids ; Feed additives ; Fermentation ; Food ; Gene expression ; Gene Expression Regulation - drug effects ; Glucose ; High fat diet ; Inflammation ; Insulin ; Insulin Resistance ; Intestinal microflora ; Intestines - drug effects ; Intestines - microbiology ; Laboratory animals ; Lactobacillus paracasei ; Linoleic Acids, Conjugated - metabolism ; Lipid metabolism ; Lipids ; Male ; Medicine ; Metabolism ; Metagenome - drug effects ; Metagenome - physiology ; Mice ; Mice, Inbred C57BL ; Microbiota ; Microbiota (Symbiotic organisms) ; Molecular Weight ; Nutrients ; Nutrition research ; Obesity ; Obesity - diet therapy ; Obesity - etiology ; Obesity - metabolism ; Obesity - microbiology ; Oxidation ; Physiological aspects ; Polymerization ; Prebiotics ; Prevotella - physiology ; Proteins ; Rodents ; Studies ; Subcutaneous Fat - drug effects ; Subcutaneous Fat - metabolism ; Triticum - chemistry ; Wheat ; Xylans - chemistry ; Xylans - pharmacology ; Xylans - therapeutic use</subject><ispartof>PloS one, 2011-06, Vol.6 (6), p.e20944</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Neyrinck et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Neyrinck et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c757t-ab43bf58ad605eeda14da32aa3ad688e2adb2940f84bf6168577da127f6cae383</citedby><cites>FETCH-LOGICAL-c757t-ab43bf58ad605eeda14da32aa3ad688e2adb2940f84bf6168577da127f6cae383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111466/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111466/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21695273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neyrinck, Audrey M</creatorcontrib><creatorcontrib>Possemiers, Sam</creatorcontrib><creatorcontrib>Druart, Céline</creatorcontrib><creatorcontrib>Van de Wiele, Tom</creatorcontrib><creatorcontrib>De Backer, Fabienne</creatorcontrib><creatorcontrib>Cani, Patrice D</creatorcontrib><creatorcontrib>Larondelle, Yvan</creatorcontrib><creatorcontrib>Delzenne, Nathalie M</creatorcontrib><title>Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Alterations in the composition of gut microbiota--known as dysbiosis--has been proposed to contribute to the development of obesity, thereby supporting the potential interest of nutrients targeting the gut with beneficial effect for host adiposity. We test the ability of a specific concentrate of water-extractable high molecular weight arabinoxylans (AX) from wheat to modulate both the gut microbiota and lipid metabolism in high-fat (HF) diet-induced obese mice.
Mice were fed either a control diet (CT) or a HF diet, or a HF diet supplemented with AX (10% w/w) during 4 weeks. AX supplementation restored the number of bacteria that were decreased upon HF feeding, i.e. Bacteroides-Prevotella spp. and Roseburia spp. Importantly, AX treatment markedly increased caecal bifidobacteria content, in particular Bifidobacterium animalis lactis. This effect was accompanied by improvement of gut barrier function and by a lower circulating inflammatory marker. Interestingly, rumenic acid (C18:2 c9,t11) was increased in white adipose tissue due to AX treatment, suggesting the influence of gut bacterial metabolism on host tissue. In parallel, AX treatment decreased adipocyte size and HF diet-induced expression of genes mediating differentiation, fatty acid uptake, fatty acid oxidation and inflammation, and decreased a key lipogenic enzyme activity in the subcutaneous adipose tissue. Furthermore, AX treatment significantly decreased HF-induced adiposity, body weight gain, serum and hepatic cholesterol accumulation and insulin resistance. Correlation analysis reveals that Roseburia spp. and Bacteroides/Prevotella levels inversely correlate with these host metabolic parameters.
Supplementation of a concentrate of water-extractable high molecular weight AX in the diet counteracted HF-induced gut dysbiosis together with an improvement of obesity and lipid-lowering effects. We postulate that hypocholesterolemic, anti-inflammatory and anti-obesity effects are related to changes in gut microbiota. These data support a role for wheat AX as interesting nutrients with prebiotic properties related to obesity prevention.</description><subject>Adipose tissue</subject><subject>Agriculture</subject><subject>Analysis</subject><subject>Animals</subject><subject>Arabinoxylans</subject><subject>Bacteria</subject><subject>Bacterial Load - drug effects</subject><subject>Bacteroides - physiology</subject><subject>Bifidobacterium - physiology</subject><subject>Biology</subject><subject>Biomarkers - metabolism</subject><subject>Body weight</subject><subject>Body Weight - drug effects</subject><subject>Body weight gain</subject><subject>Carbohydrates</subject><subject>Chemistry</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Colon</subject><subject>Correlation analysis</subject><subject>Diet</subject><subject>Diet - adverse effects</subject><subject>Dietary Fats - adverse effects</subject><subject>Dysbacteriosis</subject><subject>Ecology</subject><subject>Enzymatic activity</subject><subject>Enzyme activity</subject><subject>Fat metabolism</subject><subject>Fatty acids</subject><subject>Feed additives</subject><subject>Fermentation</subject><subject>Food</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Glucose</subject><subject>High fat diet</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Intestinal microflora</subject><subject>Intestines - drug effects</subject><subject>Intestines - microbiology</subject><subject>Laboratory animals</subject><subject>Lactobacillus paracasei</subject><subject>Linoleic Acids, Conjugated - metabolism</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Male</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Metagenome - drug effects</subject><subject>Metagenome - physiology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Molecular Weight</subject><subject>Nutrients</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Obesity - diet therapy</subject><subject>Obesity - etiology</subject><subject>Obesity - metabolism</subject><subject>Obesity - microbiology</subject><subject>Oxidation</subject><subject>Physiological aspects</subject><subject>Polymerization</subject><subject>Prebiotics</subject><subject>Prevotella - physiology</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Studies</subject><subject>Subcutaneous Fat - drug effects</subject><subject>Subcutaneous Fat - metabolism</subject><subject>Triticum - chemistry</subject><subject>Wheat</subject><subject>Xylans - chemistry</subject><subject>Xylans - pharmacology</subject><subject>Xylans - therapeutic use</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tq3DAQhk1padK0b1BaQaFQ6G4ky5a9N4U09LAQSEkPt2JkjXYVvNZWktPkNfrElbNOWEMLRRcext_8M_zSZNlzRueMV-z40vW-g3a-dR3OKc3poigeZIdswfOZyCl_uBcfZE9CuKS05LUQj7ODnIlFmVf8MPv9xaOyLtqGoDHYxECcIb_WCJGAB2U7d33TQkc8thBRk-hIXCOxXeMRwhAQZY3VTkET0Vt4Sy5cQNWnkECnyfvbvLMaw3FqduUiti0MddpinNlO903SdQqT2sY2-DR7ZKAN-Gz8HmXfP374dvp5dnb-aXl6cjZrqrKKM1AFV6asQQtaImpghQaeA_CUqWvMQat8UVBTF8oIJuqyqhKUV0Y0gLzmR9nLne62dUGOdgbJOC0EF7koE7HcEdrBpdx6uwF_Ix1YeZtwfiXBJ-talEjVAgxFvuCmMDXUDLUxRsHQWuHQ7d3YrVcb1A120UM7EZ3-6exartyV5IyxQogk8GoU8O5njyH-Y-SRWkGaynbGJbFmY0MjT4oq-VLzYhhm_hcqHY3pBtKDMjblJwVvJgWJiXgdV9CHIJdfL_6fPf8xZV_vsenVtXEdXNtH67owBYsd2HgXgkdz7xyjctiHOzfksA9y3IdU9mLf9fuiuwXgfwCjDAoj</recordid><startdate>20110609</startdate><enddate>20110609</enddate><creator>Neyrinck, Audrey M</creator><creator>Possemiers, Sam</creator><creator>Druart, Céline</creator><creator>Van de Wiele, Tom</creator><creator>De Backer, Fabienne</creator><creator>Cani, Patrice D</creator><creator>Larondelle, Yvan</creator><creator>Delzenne, Nathalie M</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110609</creationdate><title>Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice</title><author>Neyrinck, Audrey M ; Possemiers, Sam ; Druart, Céline ; Van de Wiele, Tom ; De Backer, Fabienne ; Cani, Patrice D ; Larondelle, Yvan ; Delzenne, Nathalie M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c757t-ab43bf58ad605eeda14da32aa3ad688e2adb2940f84bf6168577da127f6cae383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adipose tissue</topic><topic>Agriculture</topic><topic>Analysis</topic><topic>Animals</topic><topic>Arabinoxylans</topic><topic>Bacteria</topic><topic>Bacterial Load - 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drug effects</topic><topic>Intestines - microbiology</topic><topic>Laboratory animals</topic><topic>Lactobacillus paracasei</topic><topic>Linoleic Acids, Conjugated - metabolism</topic><topic>Lipid metabolism</topic><topic>Lipids</topic><topic>Male</topic><topic>Medicine</topic><topic>Metabolism</topic><topic>Metagenome - drug effects</topic><topic>Metagenome - physiology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Molecular Weight</topic><topic>Nutrients</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Obesity - diet therapy</topic><topic>Obesity - etiology</topic><topic>Obesity - metabolism</topic><topic>Obesity - microbiology</topic><topic>Oxidation</topic><topic>Physiological aspects</topic><topic>Polymerization</topic><topic>Prebiotics</topic><topic>Prevotella - physiology</topic><topic>Proteins</topic><topic>Rodents</topic><topic>Studies</topic><topic>Subcutaneous Fat - drug effects</topic><topic>Subcutaneous Fat - metabolism</topic><topic>Triticum - chemistry</topic><topic>Wheat</topic><topic>Xylans - chemistry</topic><topic>Xylans - pharmacology</topic><topic>Xylans - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neyrinck, Audrey M</creatorcontrib><creatorcontrib>Possemiers, Sam</creatorcontrib><creatorcontrib>Druart, Céline</creatorcontrib><creatorcontrib>Van de Wiele, Tom</creatorcontrib><creatorcontrib>De Backer, Fabienne</creatorcontrib><creatorcontrib>Cani, Patrice D</creatorcontrib><creatorcontrib>Larondelle, Yvan</creatorcontrib><creatorcontrib>Delzenne, Nathalie M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neyrinck, Audrey M</au><au>Possemiers, Sam</au><au>Druart, Céline</au><au>Van de Wiele, Tom</au><au>De Backer, Fabienne</au><au>Cani, Patrice D</au><au>Larondelle, Yvan</au><au>Delzenne, Nathalie M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-06-09</date><risdate>2011</risdate><volume>6</volume><issue>6</issue><spage>e20944</spage><pages>e20944-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Alterations in the composition of gut microbiota--known as dysbiosis--has been proposed to contribute to the development of obesity, thereby supporting the potential interest of nutrients targeting the gut with beneficial effect for host adiposity. We test the ability of a specific concentrate of water-extractable high molecular weight arabinoxylans (AX) from wheat to modulate both the gut microbiota and lipid metabolism in high-fat (HF) diet-induced obese mice.
Mice were fed either a control diet (CT) or a HF diet, or a HF diet supplemented with AX (10% w/w) during 4 weeks. AX supplementation restored the number of bacteria that were decreased upon HF feeding, i.e. Bacteroides-Prevotella spp. and Roseburia spp. Importantly, AX treatment markedly increased caecal bifidobacteria content, in particular Bifidobacterium animalis lactis. This effect was accompanied by improvement of gut barrier function and by a lower circulating inflammatory marker. Interestingly, rumenic acid (C18:2 c9,t11) was increased in white adipose tissue due to AX treatment, suggesting the influence of gut bacterial metabolism on host tissue. In parallel, AX treatment decreased adipocyte size and HF diet-induced expression of genes mediating differentiation, fatty acid uptake, fatty acid oxidation and inflammation, and decreased a key lipogenic enzyme activity in the subcutaneous adipose tissue. Furthermore, AX treatment significantly decreased HF-induced adiposity, body weight gain, serum and hepatic cholesterol accumulation and insulin resistance. Correlation analysis reveals that Roseburia spp. and Bacteroides/Prevotella levels inversely correlate with these host metabolic parameters.
Supplementation of a concentrate of water-extractable high molecular weight AX in the diet counteracted HF-induced gut dysbiosis together with an improvement of obesity and lipid-lowering effects. We postulate that hypocholesterolemic, anti-inflammatory and anti-obesity effects are related to changes in gut microbiota. These data support a role for wheat AX as interesting nutrients with prebiotic properties related to obesity prevention.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21695273</pmid><doi>10.1371/journal.pone.0020944</doi><tpages>e20944</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2011-06, Vol.6 (6), p.e20944 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1304636265 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adipose tissue Agriculture Analysis Animals Arabinoxylans Bacteria Bacterial Load - drug effects Bacteroides - physiology Bifidobacterium - physiology Biology Biomarkers - metabolism Body weight Body Weight - drug effects Body weight gain Carbohydrates Chemistry Cholesterol Cholesterol - blood Colon Correlation analysis Diet Diet - adverse effects Dietary Fats - adverse effects Dysbacteriosis Ecology Enzymatic activity Enzyme activity Fat metabolism Fatty acids Feed additives Fermentation Food Gene expression Gene Expression Regulation - drug effects Glucose High fat diet Inflammation Insulin Insulin Resistance Intestinal microflora Intestines - drug effects Intestines - microbiology Laboratory animals Lactobacillus paracasei Linoleic Acids, Conjugated - metabolism Lipid metabolism Lipids Male Medicine Metabolism Metagenome - drug effects Metagenome - physiology Mice Mice, Inbred C57BL Microbiota Microbiota (Symbiotic organisms) Molecular Weight Nutrients Nutrition research Obesity Obesity - diet therapy Obesity - etiology Obesity - metabolism Obesity - microbiology Oxidation Physiological aspects Polymerization Prebiotics Prevotella - physiology Proteins Rodents Studies Subcutaneous Fat - drug effects Subcutaneous Fat - metabolism Triticum - chemistry Wheat Xylans - chemistry Xylans - pharmacology Xylans - therapeutic use |
| title | Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice |
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