Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior
Autism is a neurodevelopmental disorder with a strong genetic component. Core symptoms are abnormal reciprocal social interactions, qualitative impairments in communication, and repetitive and stereotyped patterns of behavior with restricted interests. Candidate genes for autism include the SHANK ge...
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| description | Autism is a neurodevelopmental disorder with a strong genetic component. Core symptoms are abnormal reciprocal social interactions, qualitative impairments in communication, and repetitive and stereotyped patterns of behavior with restricted interests. Candidate genes for autism include the SHANK gene family, as mutations in SHANK2 and SHANK3 have been detected in several autistic individuals. SHANK genes code for a family of scaffolding proteins located in the postsynaptic density of excitatory synapses. To test the hypothesis that a mutation in SHANK1 contributes to the symptoms of autism, we evaluated Shank1(-/-) null mutant mice for behavioral phenotypes with relevance to autism, focusing on social communication. Ultrasonic vocalizations and the deposition of scent marks appear to be two major modes of mouse communication. Our findings revealed evidence for low levels of ultrasonic vocalizations and scent marks in Shank1(-/-) mice as compared to wildtype Shank1(+/+) littermate controls. Shank1(-/-) pups emitted fewer vocalizations than Shank1(+/+) pups when isolated from mother and littermates. In adulthood, genotype affected scent marking behavior in the presence of female urinary pheromones. Adult Shank1(-/-) males deposited fewer scent marks in proximity to female urine than Shank1(+/+) males. Call emission in response to female urinary pheromones also differed between genotypes. Shank1(+/+) mice changed their calling pattern dependent on previous female interactions, while Shank1(-/-) mice were unaffected, indicating a failure of Shank1(-/-) males to learn from a social experience. The reduced levels of ultrasonic vocalizations and scent marking behavior in Shank1(-/-) mice are consistent with a phenotype relevant to social communication deficits in autism. |
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Core symptoms are abnormal reciprocal social interactions, qualitative impairments in communication, and repetitive and stereotyped patterns of behavior with restricted interests. Candidate genes for autism include the SHANK gene family, as mutations in SHANK2 and SHANK3 have been detected in several autistic individuals. SHANK genes code for a family of scaffolding proteins located in the postsynaptic density of excitatory synapses. To test the hypothesis that a mutation in SHANK1 contributes to the symptoms of autism, we evaluated Shank1(-/-) null mutant mice for behavioral phenotypes with relevance to autism, focusing on social communication. Ultrasonic vocalizations and the deposition of scent marks appear to be two major modes of mouse communication. Our findings revealed evidence for low levels of ultrasonic vocalizations and scent marks in Shank1(-/-) mice as compared to wildtype Shank1(+/+) littermate controls. Shank1(-/-) pups emitted fewer vocalizations than Shank1(+/+) pups when isolated from mother and littermates. In adulthood, genotype affected scent marking behavior in the presence of female urinary pheromones. Adult Shank1(-/-) males deposited fewer scent marks in proximity to female urine than Shank1(+/+) males. Call emission in response to female urinary pheromones also differed between genotypes. Shank1(+/+) mice changed their calling pattern dependent on previous female interactions, while Shank1(-/-) mice were unaffected, indicating a failure of Shank1(-/-) males to learn from a social experience. The reduced levels of ultrasonic vocalizations and scent marking behavior in Shank1(-/-) mice are consistent with a phenotype relevant to social communication deficits in autism.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0020631</identifier><identifier>PMID: 21695253</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aging - metabolism ; Amphetamines ; Animal behavior ; Animals ; Autism ; Behavior ; Biology ; Body Temperature - physiology ; Body Weight - physiology ; Chemical communication ; Cocaine ; Communication ; Experiments ; Female ; Females ; Genes ; Genetic aspects ; Genotypes ; Laboratories ; Male ; Males ; Marking ; Marking behavior ; Medicine ; Membrane Proteins - deficiency ; Membrane Proteins - metabolism ; Memory ; Mental health ; Mice ; Mutation ; Nerve Tissue Proteins ; Neurodevelopmental disorders ; Neurosciences ; Odorants ; Phenotypes ; Pheromones ; Physiological psychology ; Physiology ; Postsynaptic density ; Proteins ; Reflex - physiology ; Rodents ; Scaffolding ; Scent marking behavior ; Social and Behavioral Sciences ; Social aspects ; Social behavior ; Social factors ; Social interactions ; Stereotyped behavior ; Synapses ; Trends ; Ultrasonics ; Urine ; Vocalization behavior ; Vocalization, Animal - physiology</subject><ispartof>PloS one, 2011-06, Vol.6 (6), p.e20631-e20631</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011. This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c757t-183a3bcf00d82489fbdbc54f95b5dbac6f1a699d954d8570dd027170004f2f4b3</citedby><cites>FETCH-LOGICAL-c757t-183a3bcf00d82489fbdbc54f95b5dbac6f1a699d954d8570dd027170004f2f4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111434/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111434/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21695253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wöhr, Markus</creatorcontrib><creatorcontrib>Roullet, Florence I</creatorcontrib><creatorcontrib>Hung, Albert Y</creatorcontrib><creatorcontrib>Sheng, Morgan</creatorcontrib><creatorcontrib>Crawley, Jacqueline N</creatorcontrib><title>Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Autism is a neurodevelopmental disorder with a strong genetic component. Core symptoms are abnormal reciprocal social interactions, qualitative impairments in communication, and repetitive and stereotyped patterns of behavior with restricted interests. Candidate genes for autism include the SHANK gene family, as mutations in SHANK2 and SHANK3 have been detected in several autistic individuals. SHANK genes code for a family of scaffolding proteins located in the postsynaptic density of excitatory synapses. To test the hypothesis that a mutation in SHANK1 contributes to the symptoms of autism, we evaluated Shank1(-/-) null mutant mice for behavioral phenotypes with relevance to autism, focusing on social communication. Ultrasonic vocalizations and the deposition of scent marks appear to be two major modes of mouse communication. Our findings revealed evidence for low levels of ultrasonic vocalizations and scent marks in Shank1(-/-) mice as compared to wildtype Shank1(+/+) littermate controls. Shank1(-/-) pups emitted fewer vocalizations than Shank1(+/+) pups when isolated from mother and littermates. In adulthood, genotype affected scent marking behavior in the presence of female urinary pheromones. Adult Shank1(-/-) males deposited fewer scent marks in proximity to female urine than Shank1(+/+) males. Call emission in response to female urinary pheromones also differed between genotypes. Shank1(+/+) mice changed their calling pattern dependent on previous female interactions, while Shank1(-/-) mice were unaffected, indicating a failure of Shank1(-/-) males to learn from a social experience. The reduced levels of ultrasonic vocalizations and scent marking behavior in Shank1(-/-) mice are consistent with a phenotype relevant to social communication deficits in autism.</description><subject>Aging - metabolism</subject><subject>Amphetamines</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Autism</subject><subject>Behavior</subject><subject>Biology</subject><subject>Body Temperature - physiology</subject><subject>Body Weight - physiology</subject><subject>Chemical communication</subject><subject>Cocaine</subject><subject>Communication</subject><subject>Experiments</subject><subject>Female</subject><subject>Females</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genotypes</subject><subject>Laboratories</subject><subject>Male</subject><subject>Males</subject><subject>Marking</subject><subject>Marking behavior</subject><subject>Medicine</subject><subject>Membrane Proteins - deficiency</subject><subject>Membrane Proteins - metabolism</subject><subject>Memory</subject><subject>Mental health</subject><subject>Mice</subject><subject>Mutation</subject><subject>Nerve Tissue Proteins</subject><subject>Neurodevelopmental disorders</subject><subject>Neurosciences</subject><subject>Odorants</subject><subject>Phenotypes</subject><subject>Pheromones</subject><subject>Physiological psychology</subject><subject>Physiology</subject><subject>Postsynaptic density</subject><subject>Proteins</subject><subject>Reflex - physiology</subject><subject>Rodents</subject><subject>Scaffolding</subject><subject>Scent marking behavior</subject><subject>Social and Behavioral Sciences</subject><subject>Social aspects</subject><subject>Social behavior</subject><subject>Social factors</subject><subject>Social interactions</subject><subject>Stereotyped behavior</subject><subject>Synapses</subject><subject>Trends</subject><subject>Ultrasonics</subject><subject>Urine</subject><subject>Vocalization behavior</subject><subject>Vocalization, Animal - physiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1tv0zAUgCMEYmPwDxBYQgLx0GLHdhLzgDRVXCpNmsSAV8vxpXXn2J2dlMuvx22zqUV7QHlwZH_ns318TlE8R3CKcI3ercIQvXDTdfB6CmEJK4weFKeI4XJSlRA_PPg_KZ6ktIKQ4qaqHhcnJaoYLSk-LX7OQtcN3krR2-CB7dbCxk77PgHrQWelBk7Ia-sX4Gop_DV6D6JWg9QKOL3RLoFgwOD6KFLIFrAJUjj7Z2dLQHgFksw20Im4k7R6KTY2xKfFIyNc0s_G8az4_unjt9mXycXl5_ns_GIia1r3E9RggVtpIFRNSRpmWtVKSgyjLVWtkJVBomJMMUpUQ2uoFCxrVEMIiSkNafFZ8XLvXbuQ-JizxBGGpMK0pjQT8z2hgljxdbT5qL95EJbvJkJccBF7K53mBFJGK2ogyX6kKasNZLAqGTQ1Ikpl14dxt6HttNrePAp3JD1e8XbJF2HDMUKIYJIFb0ZBDDeDTj3vbE6gc8LrMCTe1JgwitmWfPUPef_lRmoh8vmtNyFvK7dOfk7qqmmaXEqZmt5D5U_pXAG5vozN80cBb48CMtPrX_1CDCnx-dXX_2cvfxyzrw_YpRauX6bghl01HYNkD8oYUora3OUYQb5tj9ts8G178LE9ctiLw_e5C7rtB_wXihgLHw</recordid><startdate>20110609</startdate><enddate>20110609</enddate><creator>Wöhr, Markus</creator><creator>Roullet, Florence I</creator><creator>Hung, Albert Y</creator><creator>Sheng, Morgan</creator><creator>Crawley, Jacqueline N</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110609</creationdate><title>Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior</title><author>Wöhr, Markus ; Roullet, Florence I ; Hung, Albert Y ; Sheng, Morgan ; Crawley, Jacqueline N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c757t-183a3bcf00d82489fbdbc54f95b5dbac6f1a699d954d8570dd027170004f2f4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aging - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wöhr, Markus</au><au>Roullet, Florence I</au><au>Hung, Albert Y</au><au>Sheng, Morgan</au><au>Crawley, Jacqueline N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-06-09</date><risdate>2011</risdate><volume>6</volume><issue>6</issue><spage>e20631</spage><epage>e20631</epage><pages>e20631-e20631</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Autism is a neurodevelopmental disorder with a strong genetic component. Core symptoms are abnormal reciprocal social interactions, qualitative impairments in communication, and repetitive and stereotyped patterns of behavior with restricted interests. Candidate genes for autism include the SHANK gene family, as mutations in SHANK2 and SHANK3 have been detected in several autistic individuals. SHANK genes code for a family of scaffolding proteins located in the postsynaptic density of excitatory synapses. To test the hypothesis that a mutation in SHANK1 contributes to the symptoms of autism, we evaluated Shank1(-/-) null mutant mice for behavioral phenotypes with relevance to autism, focusing on social communication. Ultrasonic vocalizations and the deposition of scent marks appear to be two major modes of mouse communication. Our findings revealed evidence for low levels of ultrasonic vocalizations and scent marks in Shank1(-/-) mice as compared to wildtype Shank1(+/+) littermate controls. Shank1(-/-) pups emitted fewer vocalizations than Shank1(+/+) pups when isolated from mother and littermates. In adulthood, genotype affected scent marking behavior in the presence of female urinary pheromones. Adult Shank1(-/-) males deposited fewer scent marks in proximity to female urine than Shank1(+/+) males. Call emission in response to female urinary pheromones also differed between genotypes. Shank1(+/+) mice changed their calling pattern dependent on previous female interactions, while Shank1(-/-) mice were unaffected, indicating a failure of Shank1(-/-) males to learn from a social experience. The reduced levels of ultrasonic vocalizations and scent marking behavior in Shank1(-/-) mice are consistent with a phenotype relevant to social communication deficits in autism.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21695253</pmid><doi>10.1371/journal.pone.0020631</doi><tpages>e20631</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aging - metabolism Amphetamines Animal behavior Animals Autism Behavior Biology Body Temperature - physiology Body Weight - physiology Chemical communication Cocaine Communication Experiments Female Females Genes Genetic aspects Genotypes Laboratories Male Males Marking Marking behavior Medicine Membrane Proteins - deficiency Membrane Proteins - metabolism Memory Mental health Mice Mutation Nerve Tissue Proteins Neurodevelopmental disorders Neurosciences Odorants Phenotypes Pheromones Physiological psychology Physiology Postsynaptic density Proteins Reflex - physiology Rodents Scaffolding Scent marking behavior Social and Behavioral Sciences Social aspects Social behavior Social factors Social interactions Stereotyped behavior Synapses Trends Ultrasonics Urine Vocalization behavior Vocalization, Animal - physiology |
| title | Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T21%3A07%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Communication%20impairments%20in%20mice%20lacking%20Shank1:%20reduced%20levels%20of%20ultrasonic%20vocalizations%20and%20scent%20marking%20behavior&rft.jtitle=PloS%20one&rft.au=W%C3%B6hr,%20Markus&rft.date=2011-06-09&rft.volume=6&rft.issue=6&rft.spage=e20631&rft.epage=e20631&rft.pages=e20631-e20631&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0020631&rft_dat=%3Cgale_plos_%3EA476888371%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1304635755&rft_id=info:pmid/21695253&rft_galeid=A476888371&rft_doaj_id=oai_doaj_org_article_4059565f040041e597f0906290f714dd&rfr_iscdi=true |