SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor

Short chain fatty acids (SCFAs) have recently attracted attention as potential mediators of the effects of gut microbiota on intestinal inflammation. Some of these effects have been suggested to occur through the direct actions of SCFAs on the GPR43 receptor in neutrophils, though the precise role o...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e21205-e21205
Hauptverfasser:	Vinolo, Marco A R, Ferguson, G John, Kulkarni, Suhasini, Damoulakis, George, Anderson, Karen, Bohlooly-Y, Mohammad, Stephens, Len, Hawkins, Phillip T, Curi, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetanilide Acetic acid Animals Biology Biophysics Blotting, Western Bone marrow Cell activation Cellular signal transduction Chemokines Chemotaxis Chemotaxis, Leukocyte - drug effects Coating effects Colon Cytokines Diabetes Esters Extracellular signal-regulated kinase Fatty acids Fatty Acids - pharmacology Fibrin Fibrinogen Inflammation Inflammatory bowel disease Intestinal microflora Intestine Kinases Large intestine Leukocytes (neutrophilic) Low concentrations Medicine Mice Mice, Knockout Microbiota Microbiota (Symbiotic organisms) Motility Neutrophils Neutrophils - cytology Neutrophils - drug effects Pertussis Pertussis toxin Pharmacology Phenylacetamide Phosphorylation Physiology Polycarbonate Propionic acid Proteins R&D Rac1 protein Rac2 protein Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - physiology Research & development Ribosomal protein S6 Rodents TOR protein Transduction
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