Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation

Local mRNA translation in neurons has been mostly studied during axon guidance and synapse formation but not during initial neurite outgrowth. We performed a genome-wide screen for neurite-enriched mRNAs and identified an mRNA that encodes mitogen-activated protein kinase kinase 7 (MKK7), a MAP kina...

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Veröffentlicht in:	PLoS biology 2012-12, Vol.10 (12), p.e1001439-e1001439
Hauptverfasser:	Feltrin, Daniel, Fusco, Ludovico, Witte, Harald, Moretti, Francesca, Martin, Katrin, Letzelter, Michel, Fluri, Erika, Scheiffele, Peter, Pertz, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Animals Base Sequence Biology Cell Differentiation Cell Line Cells Genetic aspects Genetic translation Genome - genetics Growth Cones - enzymology Health aspects Hippocampus - cytology JNK Mitogen-Activated Protein Kinases - metabolism Kinases MAP Kinase Kinase 7 - metabolism MAP Kinase Signaling System Messenger RNA Mice Microtubule-Associated Proteins - metabolism Microtubules - metabolism Mitogen-activated protein kinases Models, Biological Neural transmission Neurites - enzymology Neurites - metabolism Neurons Phosphorylation Phosphothreonine - metabolism Physiological aspects Protein Biosynthesis Proteins Reproducibility of Results RNA Transport RNA, Messenger - genetics RNA, Messenger - metabolism Time Factors
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