The mechanism of toxicity in HET-S/HET-s prion incompatibility

The HET-s protein from the filamentous fungus Podospora anserina is a prion involved in a cell death reaction termed heterokaryon incompatibility. This reaction is observed at the point of contact between two genetically distinct strains when one harbors a HET-s prion (in the form of amyloid aggrega...

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Veröffentlicht in:	PLoS biology 2012-12, Vol.10 (12), p.e1001451
Hauptverfasser:	Seuring, Carolin, Greenwald, Jason, Wasmer, Christian, Wepf, Roger, Saupe, Sven J, Meier, Beat H, Riek, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amyloid - ultrastructure Biology Cell death Cell Membrane - drug effects Cell Membrane - metabolism Cellular Biology Escherichia coli - cytology Escherichia coli - drug effects Freeze Fracturing Fungal Proteins - chemistry Fungal Proteins - toxicity Fungi Health aspects Life Sciences Liposomes - metabolism Magnetic Resonance Spectroscopy Medicine Models, Biological Molecular Sequence Data Mycotoxins - toxicity NMR Nuclear magnetic resonance Phenotype Phosphorylcholine - analogs & derivatives Phosphorylcholine - pharmacology Physiological aspects Podospora - metabolism Podospora - ultrastructure Prions Prions - toxicity Prions - ultrastructure Protein Multimerization - drug effects Protein Structure, Secondary Protein Structure, Tertiary Proteins Sequence Alignment Thermodynamics Toxicity
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