Combinatorial activation and repression by seven transcription factors specify Drosophila odorant receptor expression

The mechanism that specifies olfactory sensory neurons to express only one odorant receptor (OR) from a large repertoire is critical for odor discrimination but poorly understood. Here, we describe the first comprehensive analysis of OR expression regulation in Drosophila. A systematic, RNAi-mediate...

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Veröffentlicht in:	PLoS biology 2012-03, Vol.10 (3), p.e1001280
Hauptverfasser:	Jafari, Shadi, Alkhori, Liza, Schleiffer, Alexander, Brochtrup, Anna, Hummel, Thomas, Alenius, Mattias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal genetics Animals Arthropod Antennae - cytology Arthropod Antennae - metabolism Arthropod Antennae - physiology Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Binding Sites Bioinformatics Biology Computational Biology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila Drosophila - genetics Drosophila - metabolism Drosophila - physiology Drosophila Proteins - genetics Drosophila Proteins - metabolism Gene expression Gene Expression Regulation, Developmental Gene Knockdown Techniques Genes, Insect Genetic aspects Insects MEDICIN MEDICINE Mutagenesis, Insertional Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons Neurons - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Nucleotide Motifs Physiological aspects POU Domain Factors - genetics POU Domain Factors - metabolism Promoter Regions, Genetic Receptors, Odorant - genetics Receptors, Odorant - metabolism RNA Interference Rodents Sensory Receptor Cells - cytology Sensory Receptor Cells - metabolism Sensory Receptor Cells - physiology Smell Species Specificity Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation
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