Nonheritable cellular variability accelerates the evolutionary processes of cancer

Recent cancer studies emphasize that genetic and heritable epigenetic changes drive the evolutionary rate of cancer progression and drug resistance. We discuss the ways in which nonheritable aspects of cellular variability may significantly increase evolutionary rate. Nonheritable variability arises...

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Veröffentlicht in:	PLoS biology 2012-04, Vol.10 (4), p.e1001296
Hauptverfasser:	Frank, Steven A, Rosner, Marsha Rich
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biology Cancer Cell Transformation, Neoplastic Drug resistance Drug Resistance, Neoplasm Epigenetic inheritance Evolution Genetic aspects Genetics Health aspects Homeostasis Humans Medical research Medicine Mutation Neoplasms - drug therapy Neoplasms - pathology Phenotype Physiological aspects Proteins
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