A blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreception
The circadian clock is synchronized with the day-night cycle primarily by light. Fish represent fascinating models for deciphering the light input pathway to the vertebrate clock since fish cell clocks are regulated by direct light exposure. Here we have performed a comparative, functional analysis...
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| Veröffentlicht in: | PLoS biology 2011-09, Vol.9 (9), p.e1001142-e1001142 |
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| creator | Cavallari, Nicola Frigato, Elena Vallone, Daniela Fröhlich, Nadine Lopez-Olmeda, Jose Fernando Foà, Augusto Berti, Roberto Sánchez-Vázquez, Francisco Javier Bertolucci, Cristiano Foulkes, Nicholas S |
| description | The circadian clock is synchronized with the day-night cycle primarily by light. Fish represent fascinating models for deciphering the light input pathway to the vertebrate clock since fish cell clocks are regulated by direct light exposure. Here we have performed a comparative, functional analysis of the circadian clock involving the zebrafish that is normally exposed to the day-night cycle and a cavefish species that has evolved in perpetual darkness. Our results reveal that the cavefish retains a food-entrainable clock that oscillates with an infradian period. Importantly, however, this clock is not regulated by light. This comparative study pinpoints the two extra-retinal photoreceptors Melanopsin (Opn4m2) and TMT-opsin as essential upstream elements of the peripheral clock light input pathway. |
| doi_str_mv | 10.1371/journal.pbio.1001142 |
| format | Article |
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Fish represent fascinating models for deciphering the light input pathway to the vertebrate clock since fish cell clocks are regulated by direct light exposure. Here we have performed a comparative, functional analysis of the circadian clock involving the zebrafish that is normally exposed to the day-night cycle and a cavefish species that has evolved in perpetual darkness. Our results reveal that the cavefish retains a food-entrainable clock that oscillates with an infradian period. Importantly, however, this clock is not regulated by light. This comparative study pinpoints the two extra-retinal photoreceptors Melanopsin (Opn4m2) and TMT-opsin as essential upstream elements of the peripheral clock light input pathway.</description><identifier>ISSN: 1545-7885</identifier><identifier>ISSN: 1544-9173</identifier><identifier>EISSN: 1545-7885</identifier><identifier>DOI: 10.1371/journal.pbio.1001142</identifier><identifier>PMID: 21909239</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Biological clocks ; Biology ; Cell Line ; Circadian Clocks - physiology ; Circadian rhythm ; Circadian Rhythm - physiology ; Circadian rhythms ; Danio rerio ; Evolution ; Feeding Behavior ; Freshwater ; Gene Expression ; Genotype & phenotype ; Ixodidae ; Mutation ; Opsins - genetics ; Opsins - metabolism ; Photic Stimulation ; Photoreceptor Cells, Vertebrate - physiology ; Photoreceptors ; Physiological aspects ; Rod Opsins - genetics ; Rod Opsins - metabolism ; Zebrafish ; Zebrafish - physiology</subject><ispartof>PLoS biology, 2011-09, Vol.9 (9), p.e1001142-e1001142</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Cavallari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Cavallari N, Frigato E, Vallone D, Fröhlich N, Lopez-Olmeda JF, et al. (2011) A Blind Circadian Clock in Cavefish Reveals that Opsins Mediate Peripheral Clock Photoreception. 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Fish represent fascinating models for deciphering the light input pathway to the vertebrate clock since fish cell clocks are regulated by direct light exposure. Here we have performed a comparative, functional analysis of the circadian clock involving the zebrafish that is normally exposed to the day-night cycle and a cavefish species that has evolved in perpetual darkness. Our results reveal that the cavefish retains a food-entrainable clock that oscillates with an infradian period. Importantly, however, this clock is not regulated by light. This comparative study pinpoints the two extra-retinal photoreceptors Melanopsin (Opn4m2) and TMT-opsin as essential upstream elements of the peripheral clock light input pathway.</description><subject>Animals</subject><subject>Biological clocks</subject><subject>Biology</subject><subject>Cell Line</subject><subject>Circadian Clocks - physiology</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - physiology</subject><subject>Circadian rhythms</subject><subject>Danio rerio</subject><subject>Evolution</subject><subject>Feeding Behavior</subject><subject>Freshwater</subject><subject>Gene Expression</subject><subject>Genotype & phenotype</subject><subject>Ixodidae</subject><subject>Mutation</subject><subject>Opsins - genetics</subject><subject>Opsins - metabolism</subject><subject>Photic Stimulation</subject><subject>Photoreceptor Cells, Vertebrate - physiology</subject><subject>Photoreceptors</subject><subject>Physiological aspects</subject><subject>Rod Opsins - genetics</subject><subject>Rod Opsins - 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| subjects | Animals Biological clocks Biology Cell Line Circadian Clocks - physiology Circadian rhythm Circadian Rhythm - physiology Circadian rhythms Danio rerio Evolution Feeding Behavior Freshwater Gene Expression Genotype & phenotype Ixodidae Mutation Opsins - genetics Opsins - metabolism Photic Stimulation Photoreceptor Cells, Vertebrate - physiology Photoreceptors Physiological aspects Rod Opsins - genetics Rod Opsins - metabolism Zebrafish Zebrafish - physiology |
| title | A blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreception |
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