Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome

Cornelia de Lange Syndrome (CdLS) is the founding member of a class of multi-organ system birth defect syndromes termed cohesinopathies, named for the chromatin-associated protein complex cohesin, which mediates sister chromatid cohesion. Most cases of CdLS are caused by haploinsufficiency for Nippe...

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Veröffentlicht in:	PLoS biology 2011-10, Vol.9 (10), p.e1001181-e1001181
Hauptverfasser:	Muto, Akihiko, Calof, Anne L, Lander, Arthur D, Schilling, Thomas F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Biology Body Patterning - genetics Cell culture Cell Cycle Proteins - metabolism Cell division Chromosomal Proteins, Non-Histone - metabolism Cohesins De Lange syndrome De Lange Syndrome - genetics Disease Models, Animal Endoderm - metabolism Experiments Gastrointestinal Tract - abnormalities Gastrointestinal Tract - growth & development Gastrulation Gene Expression Gene Expression Regulation, Developmental Gene Knockdown Techniques Gene mutations Genetic aspects Genetic engineering Health aspects Heart Heart - growth & development Heart Defects, Congenital - genetics Hypotheses Insects Medicine Morpholinos - genetics Phenotype Protein Interaction Domains and Motifs Proteins Risk factors Sequence Homology, Amino Acid SOX Transcription Factors - genetics SOX Transcription Factors - metabolism Studies Transcriptional Activation Zebrafish Zebrafish - abnormalities Zebrafish - genetics Zebrafish - growth & development Zebrafish Proteins - deficiency Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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