Scaling behavior of human locomotor activity amplitude: association with bipolar disorder

Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of huma...

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Veröffentlicht in:PloS one 2011-05, Vol.6 (5), p.e20650-e20650
Hauptverfasser: Indic, Premananda, Salvatore, Paola, Maggini, Carlo, Ghidini, Stefano, Ferraro, Gabriella, Baldessarini, Ross J, Murray, Greg
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container_title PloS one
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creator Indic, Premananda
Salvatore, Paola
Maggini, Carlo
Ghidini, Stefano
Ferraro, Gabriella
Baldessarini, Ross J
Murray, Greg
description Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity. SCN also is implicated in the pathophysiology of bipolar disorder (BD) or manic-depressive illness, a severe, episodic disorder of mood, cognition and behaviour. Here, we investigated scaling behaviour in actigraphically recorded human motility data for potential indicators of BD, particularly its manic phase. A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients.
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subjects Adolescent
Adult
Age
Alzheimer's disease
Alzheimers disease
Archives & records
Artificial neural networks
Biology
Bipolar disorder
Bipolar Disorder - physiopathology
Circadian rhythm
Cognition
Consortia
Emotions
Female
Human behavior
Humans
Hypothalamus
Locomotor activity
Male
Mathematics
Medical research
Medicine
Mental depression
Mental disorders
Middle Aged
Mood
Motility
Motor Activity - physiology
Neural networks
Neurology
Neurosciences
Nuclei
Patients
Physics
Physiology
Population
Psychiatry
Psychosis
Scale invariance
Scaling
Schizophrenia
Social and Behavioral Sciences
Suprachiasmatic nucleus
System theory
Young Adult
Young adults
title Scaling behavior of human locomotor activity amplitude: association with bipolar disorder
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