Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer

Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest...

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Veröffentlicht in:	PLoS biology 2011-11, Vol.9 (11), p.e1001199
Hauptverfasser:	Maxwell, Christopher A, Benítez, Javier, Gómez-Baldó, Laia, Osorio, Ana, Bonifaci, Núria, Fernández-Ramires, Ricardo, Costes, Sylvain V, Guinó, Elisabet, Chen, Helen, Evans, Gareth J R, Mohan, Pooja, Català, Isabel, Petit, Anna, Aguilar, Helena, Villanueva, Alberto, Aytes, Alvaro, Serra-Musach, Jordi, Rennert, Gad, Lejbkowicz, Flavio, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Ripamonti, Carla B, Bonanni, Bernardo, Viel, Alessandra, Allavena, Anna, Bernard, Loris, Radice, Paolo, Friedman, Eitan, Kaufman, Bella, Laitman, Yael, Dubrovsky, Maya, Milgrom, Roni, Jakubowska, Anna, Cybulski, Cezary, Gorski, Bohdan, Jaworska, Katarzyna, Durda, Katarzyna, Sukiennicki, Grzegorz, Lubiński, Jan, Shugart, Yin Yao, Domchek, Susan M, Letrero, Richard, Weber, Barbara L, Hogervorst, Frans B L, Rookus, Matti A, Collee, J Margriet, Devilee, Peter, Ligtenberg, Marjolijn J, Luijt, Rob B van der, Aalfs, Cora M, Waisfisz, Quinten, Wijnen, Juul, Roozendaal, Cornelis E P van, Easton, Douglas F, Peock, Susan, Cook, Margaret, Oliver, Clare, Frost, Debra, Harrington, Patricia, Evans, D Gareth, Lalloo, Fiona, Eeles, Rosalind, Izatt, Louise, Chu, Carol, Eccles, Diana, Douglas, Fiona, Brewer, Carole, Nevanlinna, Heli, Heikkinen, Tuomas, Couch, Fergus J, Lindor, Noralane M, Wang, Xianshu, Godwin, Andrew K, Caligo, Maria A, Lombardi, Grazia, Loman, Niklas, Karlsson, Per, Ehrencrona, Hans, Wachenfeldt, Anna von, Barkardottir, Rosa Bjork, Hamann, Ute, Rashid, Muhammad U, Lasa, Adriana, Caldés, Trinidad, Andrés, Raquel, Schmitt, Michael, Assmann, Volker, Stevens, Kristen, Offit, Kenneth, Curado, João, Tilgner, Hagen, Guigó, Roderic, Aiza, Gemma, Brunet, Joan, Castellsagué, Joan, Martrat, Griselda, Urruticoechea, Ander, Blanco, Ignacio, Tihomirova, Laima
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antigens, CD44 Aurora Kinase A Aurora Kinases BASIC BIOLOGICAL SCIENCES Biologi Biological Sciences Biology Biomedical research BRCA mutations BRCA1 BRCA1 Protein BRCA1 Protein - genetics BRCA1 Protein - metabolism BRCA2 BRCA2 Protein BRCA2 Protein - genetics BRCA2 Protein - metabolism Breast Breast - cytology Breast cancer Breast Neoplasms Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer and Oncology Cancer och onkologi cancer risk factors CD44 Cell Line Cell Line, Tumor Cell Polarity Cell Polarity - genetics centrosomes Colleges & universities Confidence intervals Càncer de mama Cèl·lules epitelials Epithelial Cells Epithelial Cells - cytology Epithelial Cells - metabolism Estrogen Extracellular Matrix Proteins Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Female Genes Genes, BRCA1 Genes, BRCA2 Genetic aspects genetic causes of cancer Genetic Predisposition to Disease Genetic Variation Genotype Health aspects HeLa Cells heredity Heterozygote Hospitals Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Immunologi inom det medicinska området Immunology in the Medical Area Life Sciences Medical research Medicine Microtubules Microtubules - physiology Microtubules - ultrastructure mitosis Mutation Natural Sciences Naturvetenskap Oncogenes Oncogens Physiological aspects Polarity (Biology) protein kinases Protein Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases Receptors Receptors, Estrogen Receptors, Estrogen - analysis Risk factors Tumor
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