P130Cas attenuates epidermal growth factor (EGF) receptor internalization by modulating EGF-triggered dynamin phosphorylation

Endocytosis controls localization-specific signal transduction via epidermal growth factor receptor (EGFR), as well as downregulation of that receptor. Extracellular matrix (ECM)-integrin coupling induces formation of macromolecular complexes that include EGFR, integrin, Src kinase and p130Cas, resu...

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Veröffentlicht in:	PloS one 2011-05, Vol.6 (5), p.e20125-e20125
Hauptverfasser:	Kang, Yong Seok, Kim, Wook, Huh, Yun Hyun, Bae, Jeomil, Kim, Jin Soo, Song, Woo Keun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Biology Blotting, Western Cell activation Cell adhesion Cell adhesion & migration Cell surface Cellular signal transduction Coupling (molecular) Crk-Associated Substrate Protein - physiology Dynamin Dynamins - metabolism Endocytosis Epidermal growth factor Epidermal Growth Factor - metabolism Epidermal growth factor receptors Epidermal growth factors Extracellular matrix Fibronectin Fibronectins Fluorescent Antibody Technique Humans Integrins Internalization Kinases Localization Macromolecules Molecular modelling Phosphorylation Proteins Receptor, Epidermal Growth Factor - metabolism Regulatory proteins Rodents Signal transduction Signaling Skin cancer
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