Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescence
In cell senescence, cultured cells cease proliferating and acquire aberrant gene expression patterns. MicroRNAs (miRNAs) modulate gene expression through translational repression or mRNA degradation and have been implicated in senescence. We used deep sequencing to carry out a comprehensive survey o...
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| Veröffentlicht in: | PloS one 2011-05, Vol.6 (5), p.e20509-e20509 |
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| creator | Dhahbi, Joseph M Atamna, Hani Boffelli, Dario Magis, Wendy Spindler, Stephen R Martin, David I K |
| description | In cell senescence, cultured cells cease proliferating and acquire aberrant gene expression patterns. MicroRNAs (miRNAs) modulate gene expression through translational repression or mRNA degradation and have been implicated in senescence. We used deep sequencing to carry out a comprehensive survey of miRNA expression and involvement in cell senescence. Informatic analysis of small RNA sequence datasets from young and senescent IMR90 human fibroblasts identifies many miRNAs that are regulated (either up or down) with cell senescence. Comparison with mRNA expression profiles reveals potential mRNA targets of these senescence-regulated miRNAs. The target mRNAs are enriched for genes involved in biological processes associated with cell senescence. This result greatly extends existing information on the role of miRNAs in cell senescence and is consistent with miRNAs having a causal role in the process. |
| doi_str_mv | 10.1371/journal.pone.0020509 |
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MicroRNAs (miRNAs) modulate gene expression through translational repression or mRNA degradation and have been implicated in senescence. We used deep sequencing to carry out a comprehensive survey of miRNA expression and involvement in cell senescence. Informatic analysis of small RNA sequence datasets from young and senescent IMR90 human fibroblasts identifies many miRNAs that are regulated (either up or down) with cell senescence. Comparison with mRNA expression profiles reveals potential mRNA targets of these senescence-regulated miRNAs. The target mRNAs are enriched for genes involved in biological processes associated with cell senescence. This result greatly extends existing information on the role of miRNAs in cell senescence and is consistent with miRNAs having a causal role in the process.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0020509</identifier><identifier>PMID: 21637828</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aberration ; Aging ; Analysis ; Apoptosis ; Bayesian analysis ; Biochemistry ; Bioinformatics ; Biological activity ; Biological effects ; Biological Phenomena - genetics ; Biology ; Cancer ; Cell cycle ; Cellular Senescence - genetics ; Children & youth ; Cluster Analysis ; Databases, Genetic ; Down-Regulation - genetics ; Fibroblasts ; Fibroblasts - cytology ; Fibroblasts - metabolism ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation ; Gene sequencing ; Genes ; Genetic engineering ; Genomes ; High-Throughput Nucleotide Sequencing - methods ; Humans ; Kinases ; Leukemia ; Medicine ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; MicroRNAs - metabolism ; miRNA ; Molecular Sequence Annotation ; Nucleotide sequence ; Ribonucleic acid ; RNA ; Senescence ; Surveys ; Up-Regulation - genetics</subject><ispartof>PloS one, 2011-05, Vol.6 (5), p.e20509-e20509</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Dhahbi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Dhahbi et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-d4bf58b04856f74ad9b3ec824bc1e7af15f60f41e3cb2c30b55b13315716baed3</citedby><cites>FETCH-LOGICAL-c691t-d4bf58b04856f74ad9b3ec824bc1e7af15f60f41e3cb2c30b55b13315716baed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102725/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102725/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21637828$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dhahbi, Joseph M</creatorcontrib><creatorcontrib>Atamna, Hani</creatorcontrib><creatorcontrib>Boffelli, Dario</creatorcontrib><creatorcontrib>Magis, Wendy</creatorcontrib><creatorcontrib>Spindler, Stephen R</creatorcontrib><creatorcontrib>Martin, David I K</creatorcontrib><title>Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescence</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>In cell senescence, cultured cells cease proliferating and acquire aberrant gene expression patterns. MicroRNAs (miRNAs) modulate gene expression through translational repression or mRNA degradation and have been implicated in senescence. We used deep sequencing to carry out a comprehensive survey of miRNA expression and involvement in cell senescence. Informatic analysis of small RNA sequence datasets from young and senescent IMR90 human fibroblasts identifies many miRNAs that are regulated (either up or down) with cell senescence. Comparison with mRNA expression profiles reveals potential mRNA targets of these senescence-regulated miRNAs. The target mRNAs are enriched for genes involved in biological processes associated with cell senescence. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dhahbi, Joseph M</au><au>Atamna, Hani</au><au>Boffelli, Dario</au><au>Magis, Wendy</au><au>Spindler, Stephen R</au><au>Martin, David I K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescence</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-05-26</date><risdate>2011</risdate><volume>6</volume><issue>5</issue><spage>e20509</spage><epage>e20509</epage><pages>e20509-e20509</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>In cell senescence, cultured cells cease proliferating and acquire aberrant gene expression patterns. MicroRNAs (miRNAs) modulate gene expression through translational repression or mRNA degradation and have been implicated in senescence. We used deep sequencing to carry out a comprehensive survey of miRNA expression and involvement in cell senescence. Informatic analysis of small RNA sequence datasets from young and senescent IMR90 human fibroblasts identifies many miRNAs that are regulated (either up or down) with cell senescence. Comparison with mRNA expression profiles reveals potential mRNA targets of these senescence-regulated miRNAs. The target mRNAs are enriched for genes involved in biological processes associated with cell senescence. This result greatly extends existing information on the role of miRNAs in cell senescence and is consistent with miRNAs having a causal role in the process.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21637828</pmid><doi>10.1371/journal.pone.0020509</doi><tpages>e20509</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aberration Aging Analysis Apoptosis Bayesian analysis Biochemistry Bioinformatics Biological activity Biological effects Biological Phenomena - genetics Biology Cancer Cell cycle Cellular Senescence - genetics Children & youth Cluster Analysis Databases, Genetic Down-Regulation - genetics Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Gene expression Gene Expression Profiling Gene Expression Regulation Gene sequencing Genes Genetic engineering Genomes High-Throughput Nucleotide Sequencing - methods Humans Kinases Leukemia Medicine MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Molecular Sequence Annotation Nucleotide sequence Ribonucleic acid RNA Senescence Surveys Up-Regulation - genetics |
| title | Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescence |
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