Increased systemic glucose tolerance with increased muscle glucose uptake in transgenic mice overexpressing RXRγ in skeletal muscle

Retinoid X receptor (RXR) γ is a nuclear receptor-type transcription factor expressed mostly in skeletal muscle, and regulated by nutritional conditions. Previously, we established transgenic mice overexpressing RXRγ in skeletal muscle (RXRγ mice), which showed lower blood glucose than the control m...

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Veröffentlicht in:	PloS one 2011, Vol.6 (5), p.e20467-e20467
Hauptverfasser:	Sugita, Satoshi, Kamei, Yasutomi, Akaike, Fumiko, Suganami, Takayoshi, Kanai, Sayaka, Hattori, Maki, Manabe, Yasuko, Fujii, Nobuharu, Takai-Igarashi, Takako, Tadaishi, Miki, Oka, Jun-ichiro, Aburatani, Hiroyuki, Yamada, Tetsuya, Katagiri, Hideki, Kakehi, Saori, Tamura, Yoshifumi, Kubo, Hideo, Nishida, Kenichi, Miura, Shinji, Ezaki, Osamu, Ogawa, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Bioinformatics Biology Blood glucose Diabetes mellitus DNA microarrays Electroporation Gene expression Gene regulation Genes Glucose Glucose - metabolism Glucose tolerance Glucose transporter Glucose Transporter Type 1 - metabolism Glucose Transporter Type 4 - metabolism Glycogen - metabolism Humans In vivo methods and tests Insulin Insulin resistance Medicine Metabolism Mice Mice, Inbred C57BL Mice, Transgenic Muscle, Skeletal - metabolism Nutrition Oligonucleotide Array Sequence Analysis Peroxisome proliferator-activated receptors Polymerase Chain Reaction Retinoid X Receptor gamma - genetics Retinoid X Receptor gamma - metabolism Retinoid X receptors Rodents Skeletal muscle Transgenic mice
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