Mitochondrial changes in ageing Caenorhabditis elegans--what do we learn from superoxide dismutase knockouts?

One of the most popular damage accumulation theories of ageing is the mitochondrial free radical theory of ageing (mFRTA). The mFRTA proposes that ageing is due to the accumulation of unrepaired oxidative damage, in particular damage to mitochondrial DNA (mtDNA). Within the mFRTA, the "vicious...

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Veröffentlicht in:	PloS one 2011-05, Vol.6 (5), p.e19444
Hauptverfasser:	Gruber, Jan, Ng, Li Fang, Fong, Sheng, Wong, Yee Ting, Koh, Soon Ann, Chen, Ce-Belle, Shui, Guanghou, Cheong, Wei Fun, Schaffer, Sebastian, Wenk, Markus R, Halliwell, Barry
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Aging - metabolism Animals Biology Caenorhabditis elegans Caenorhabditis elegans - enzymology Computational Biology Damage accumulation Deoxyribonucleic acid DNA DNA damage DNA, Mitochondrial - genetics Gene Deletion Gene Dosage - genetics Gene Knockout Techniques Life span Lipids Medicine Mitochondria Mitochondria - metabolism Mitochondrial DNA Models, Biological Movement Mutants Mutation Nematodes Oxidative Stress Oxygen Phenotype Reactive oxygen species Roundworms Saccharomyces cerevisiae Superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxides Superoxides - metabolism Survival Analysis
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