Comparison of two porcine-derived materials for repairing abdominal wall defects in rats
The purpose of this study was to compare the mechanical properties, host responses and incorporation of porcine small intestine submucosa (PSIS) and porcine acellular dermal matrix (PADM) in a rat model of abdominal wall defect repair. Prior to implantation, PSIS and PADM were prepared and evaluated...
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| creator | Liu, Zhengni Tang, Rui Zhou, Zhiyuan Song, Zhicheng Wang, Huichun Gu, Yan |
| description | The purpose of this study was to compare the mechanical properties, host responses and incorporation of porcine small intestine submucosa (PSIS) and porcine acellular dermal matrix (PADM) in a rat model of abdominal wall defect repair.
Prior to implantation, PSIS and PADM were prepared and evaluated in terms of structure and mechanical properties. Full-thickness abdominal wall defects were created in 50 Sprague-Dawley rats, and were repaired using either PSIS or PADM. Rats were sacrificed 1, 2, 4, 8 and 12 weeks post-repair and examined for herniation, infection, adhesions, contraction, and changes in the thickness and strength of the tissues incorporated at the defect sites. Histopathology and immunohistochemistry were performed to analyze inflammatory responses, collagen deposition and vascularization.
PADM showed more dense collagen deposition and stronger mechanical properties than PSIS prior to implantation (P |
| doi_str_mv | 10.1371/journal.pone.0020520 |
| format | Article |
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Prior to implantation, PSIS and PADM were prepared and evaluated in terms of structure and mechanical properties. Full-thickness abdominal wall defects were created in 50 Sprague-Dawley rats, and were repaired using either PSIS or PADM. Rats were sacrificed 1, 2, 4, 8 and 12 weeks post-repair and examined for herniation, infection, adhesions, contraction, and changes in the thickness and strength of the tissues incorporated at the defect sites. Histopathology and immunohistochemistry were performed to analyze inflammatory responses, collagen deposition and vascularization.
PADM showed more dense collagen deposition and stronger mechanical properties than PSIS prior to implantation (P<0.01). However, the mechanical properties observed after integration with the surrounding native tissues was similar for PADM and PSIS. Both PADM and PSIS showed significant contraction by week 12. However, PADM tissue induced less adhesion and increased in thickness more slowly, and showed less infiltration by foreign giant cells, polymorphonuclear cells, and mononuclear cells. Improved remodeling of host tissue was observed after PSIS implantation, which was apparent from the orientation of bands of fibrous connective tissue, intermixed with newly formed blood vessels by Week 12.
PSIS showed weaker mechanical properties prior to implantation. However, after implantation PSIS induced more pronounced host responses and showed better incorporation into host tissues than PADM.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0020520</identifier><identifier>PMID: 21637777</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdomen ; Abdominal wall ; Abdominal Wall - pathology ; Animal tissues ; Animals ; Biocompatible Materials - pharmacology ; Biology ; Blood vessels ; Collagen ; Connective tissues ; Contraction ; Defects ; Deposition ; Dermis - metabolism ; Extracellular matrix ; Extracellular Matrix - drug effects ; Extracellular Matrix - ultrastructure ; Giant cells ; Health aspects ; Hernias ; Histopathology ; Immunohistochemistry ; Implantation ; Infiltration ; Inflammation ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - ultrastructure ; Intestine, Small - metabolism ; Laboratory animals ; Leukocytes (mononuclear) ; Leukocytes (polymorphonuclear) ; Male ; Materials Science ; Materials Testing ; Mechanical Phenomena - drug effects ; Mechanical properties ; Medicine ; Morphology ; Physics ; Plastic surgery ; Prostheses ; Prosthesis Implantation ; Rats ; Rats, Sprague-Dawley ; Repair ; Rodents ; Skin ; Small intestine ; Surface Properties - drug effects ; Sus scrofa ; Test methods ; Textiles ; Tissue Adhesions - pathology ; Tissue Scaffolds - chemistry ; Transplants & implants ; Vascularization ; Wound Healing - drug effects</subject><ispartof>PloS one, 2011-05, Vol.6 (5), p.e20520-e20520</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Liu et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-b731405b901151370ac1751218506b15c043b7e46b7833a6668e70feaa63e3413</citedby><cites>FETCH-LOGICAL-c691t-b731405b901151370ac1751218506b15c043b7e46b7833a6668e70feaa63e3413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102734/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102734/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2101,2927,23865,27923,27924,53790,53792,79471,79472</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21637777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lin, Samuel J.</contributor><creatorcontrib>Liu, Zhengni</creatorcontrib><creatorcontrib>Tang, Rui</creatorcontrib><creatorcontrib>Zhou, Zhiyuan</creatorcontrib><creatorcontrib>Song, Zhicheng</creatorcontrib><creatorcontrib>Wang, Huichun</creatorcontrib><creatorcontrib>Gu, Yan</creatorcontrib><title>Comparison of two porcine-derived materials for repairing abdominal wall defects in rats</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The purpose of this study was to compare the mechanical properties, host responses and incorporation of porcine small intestine submucosa (PSIS) and porcine acellular dermal matrix (PADM) in a rat model of abdominal wall defect repair.
Prior to implantation, PSIS and PADM were prepared and evaluated in terms of structure and mechanical properties. Full-thickness abdominal wall defects were created in 50 Sprague-Dawley rats, and were repaired using either PSIS or PADM. Rats were sacrificed 1, 2, 4, 8 and 12 weeks post-repair and examined for herniation, infection, adhesions, contraction, and changes in the thickness and strength of the tissues incorporated at the defect sites. Histopathology and immunohistochemistry were performed to analyze inflammatory responses, collagen deposition and vascularization.
PADM showed more dense collagen deposition and stronger mechanical properties than PSIS prior to implantation (P<0.01). However, the mechanical properties observed after integration with the surrounding native tissues was similar for PADM and PSIS. Both PADM and PSIS showed significant contraction by week 12. However, PADM tissue induced less adhesion and increased in thickness more slowly, and showed less infiltration by foreign giant cells, polymorphonuclear cells, and mononuclear cells. Improved remodeling of host tissue was observed after PSIS implantation, which was apparent from the orientation of bands of fibrous connective tissue, intermixed with newly formed blood vessels by Week 12.
PSIS showed weaker mechanical properties prior to implantation. However, after implantation PSIS induced more pronounced host responses and showed better incorporation into host tissues than PADM.</description><subject>Abdomen</subject><subject>Abdominal wall</subject><subject>Abdominal Wall - pathology</subject><subject>Animal tissues</subject><subject>Animals</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biology</subject><subject>Blood vessels</subject><subject>Collagen</subject><subject>Connective tissues</subject><subject>Contraction</subject><subject>Defects</subject><subject>Deposition</subject><subject>Dermis - metabolism</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix - drug effects</subject><subject>Extracellular Matrix - ultrastructure</subject><subject>Giant cells</subject><subject>Health aspects</subject><subject>Hernias</subject><subject>Histopathology</subject><subject>Immunohistochemistry</subject><subject>Implantation</subject><subject>Infiltration</subject><subject>Inflammation</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - ultrastructure</subject><subject>Intestine, Small - metabolism</subject><subject>Laboratory animals</subject><subject>Leukocytes (mononuclear)</subject><subject>Leukocytes (polymorphonuclear)</subject><subject>Male</subject><subject>Materials Science</subject><subject>Materials Testing</subject><subject>Mechanical Phenomena - drug effects</subject><subject>Mechanical properties</subject><subject>Medicine</subject><subject>Morphology</subject><subject>Physics</subject><subject>Plastic surgery</subject><subject>Prostheses</subject><subject>Prosthesis Implantation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Repair</subject><subject>Rodents</subject><subject>Skin</subject><subject>Small intestine</subject><subject>Surface Properties - drug effects</subject><subject>Sus scrofa</subject><subject>Test methods</subject><subject>Textiles</subject><subject>Tissue Adhesions - pathology</subject><subject>Tissue Scaffolds - chemistry</subject><subject>Transplants & implants</subject><subject>Vascularization</subject><subject>Wound Healing - drug effects</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6D0QLguLFjEnTJO2NsAx-DCws-IV34TQ9ncnSNjVJd_Xfm5npLlPZC5OLhOR53yQnb5I8p2RJmaTvruzoemiXg-1xSUhGeEYeJKe0ZNlCZIQ9PJqfJE-8vyKEs0KIx8lJRgWTsZ0mP1e2G8AZb_vUNmm4selgnTY9Lmp05hrrtIMQZ9D6tLEudTiAcabfpFDVtjPxCukNtG1aY4M6-NT0qYPgnyaPmqjBZ9N4lnz_-OHb6vPi4vLTenV-sdCipGFRSUZzwquSUMrjuwhoKjnNaMGJqCjXJGeVxFxUsmAMhBAFStIggGDIcsrOkpcH36G1Xk1F8YpmZcEFL0UZifWBqC1cqcGZDtwfZcGo_YJ1GwUuGN2iQtJQzgFpLkkOgAWjrCK6EkRqnrM8er2fThurDmuNfXDQzkznO73Zqo29VoySTO4N3kwGzv4a0QfVGa-xbaFHO3pVSJKVeVbwSL76h7z_cRO1gXh_0zc2Hqt3nuo8l6IoSr4v0vIeKvYaO6NjgBoT12eCtzNBZAL-DhsYvVfrr1_-n738MWdfH7FbhDZsvW3HYGzv52B-ALWz3jts7mpMidrl_7Yaapd_NeU_yl4c_8-d6Dbw7C-D5P5i</recordid><startdate>20110526</startdate><enddate>20110526</enddate><creator>Liu, Zhengni</creator><creator>Tang, Rui</creator><creator>Zhou, Zhiyuan</creator><creator>Song, Zhicheng</creator><creator>Wang, Huichun</creator><creator>Gu, Yan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110526</creationdate><title>Comparison of two porcine-derived materials for repairing abdominal wall defects in rats</title><author>Liu, Zhengni ; Tang, Rui ; Zhou, Zhiyuan ; Song, Zhicheng ; Wang, Huichun ; Gu, Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-b731405b901151370ac1751218506b15c043b7e46b7833a6668e70feaa63e3413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abdomen</topic><topic>Abdominal wall</topic><topic>Abdominal Wall - pathology</topic><topic>Animal tissues</topic><topic>Animals</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Biology</topic><topic>Blood vessels</topic><topic>Collagen</topic><topic>Connective tissues</topic><topic>Contraction</topic><topic>Defects</topic><topic>Deposition</topic><topic>Dermis - metabolism</topic><topic>Extracellular matrix</topic><topic>Extracellular Matrix - drug effects</topic><topic>Extracellular Matrix - ultrastructure</topic><topic>Giant cells</topic><topic>Health aspects</topic><topic>Hernias</topic><topic>Histopathology</topic><topic>Immunohistochemistry</topic><topic>Implantation</topic><topic>Infiltration</topic><topic>Inflammation</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - ultrastructure</topic><topic>Intestine, Small - metabolism</topic><topic>Laboratory animals</topic><topic>Leukocytes (mononuclear)</topic><topic>Leukocytes (polymorphonuclear)</topic><topic>Male</topic><topic>Materials Science</topic><topic>Materials Testing</topic><topic>Mechanical Phenomena - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Zhengni</au><au>Tang, Rui</au><au>Zhou, Zhiyuan</au><au>Song, Zhicheng</au><au>Wang, Huichun</au><au>Gu, Yan</au><au>Lin, Samuel J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of two porcine-derived materials for repairing abdominal wall defects in rats</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-05-26</date><risdate>2011</risdate><volume>6</volume><issue>5</issue><spage>e20520</spage><epage>e20520</epage><pages>e20520-e20520</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The purpose of this study was to compare the mechanical properties, host responses and incorporation of porcine small intestine submucosa (PSIS) and porcine acellular dermal matrix (PADM) in a rat model of abdominal wall defect repair.
Prior to implantation, PSIS and PADM were prepared and evaluated in terms of structure and mechanical properties. Full-thickness abdominal wall defects were created in 50 Sprague-Dawley rats, and were repaired using either PSIS or PADM. Rats were sacrificed 1, 2, 4, 8 and 12 weeks post-repair and examined for herniation, infection, adhesions, contraction, and changes in the thickness and strength of the tissues incorporated at the defect sites. Histopathology and immunohistochemistry were performed to analyze inflammatory responses, collagen deposition and vascularization.
PADM showed more dense collagen deposition and stronger mechanical properties than PSIS prior to implantation (P<0.01). However, the mechanical properties observed after integration with the surrounding native tissues was similar for PADM and PSIS. Both PADM and PSIS showed significant contraction by week 12. However, PADM tissue induced less adhesion and increased in thickness more slowly, and showed less infiltration by foreign giant cells, polymorphonuclear cells, and mononuclear cells. Improved remodeling of host tissue was observed after PSIS implantation, which was apparent from the orientation of bands of fibrous connective tissue, intermixed with newly formed blood vessels by Week 12.
PSIS showed weaker mechanical properties prior to implantation. However, after implantation PSIS induced more pronounced host responses and showed better incorporation into host tissues than PADM.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21637777</pmid><doi>10.1371/journal.pone.0020520</doi><tpages>e20520</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2011-05, Vol.6 (5), p.e20520-e20520 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1298565969 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abdomen Abdominal wall Abdominal Wall - pathology Animal tissues Animals Biocompatible Materials - pharmacology Biology Blood vessels Collagen Connective tissues Contraction Defects Deposition Dermis - metabolism Extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - ultrastructure Giant cells Health aspects Hernias Histopathology Immunohistochemistry Implantation Infiltration Inflammation Intestinal Mucosa - drug effects Intestinal Mucosa - ultrastructure Intestine, Small - metabolism Laboratory animals Leukocytes (mononuclear) Leukocytes (polymorphonuclear) Male Materials Science Materials Testing Mechanical Phenomena - drug effects Mechanical properties Medicine Morphology Physics Plastic surgery Prostheses Prosthesis Implantation Rats Rats, Sprague-Dawley Repair Rodents Skin Small intestine Surface Properties - drug effects Sus scrofa Test methods Textiles Tissue Adhesions - pathology Tissue Scaffolds - chemistry Transplants & implants Vascularization Wound Healing - drug effects |
| title | Comparison of two porcine-derived materials for repairing abdominal wall defects in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T12%3A51%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20two%20porcine-derived%20materials%20for%20repairing%20abdominal%20wall%20defects%20in%20rats&rft.jtitle=PloS%20one&rft.au=Liu,%20Zhengni&rft.date=2011-05-26&rft.volume=6&rft.issue=5&rft.spage=e20520&rft.epage=e20520&rft.pages=e20520-e20520&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0020520&rft_dat=%3Cgale_plos_%3EA476889541%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1298565969&rft_id=info:pmid/21637777&rft_galeid=A476889541&rft_doaj_id=oai_doaj_org_article_e0f155ae14704aae8313b0cb607c5434&rfr_iscdi=true |