A user's guide to the encyclopedia of DNA elements (ENCODE)
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a coll...
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| Veröffentlicht in: | PLoS biology 2011-04, Vol.9 (4), p.e1001046-e1001046 |
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| description | The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome. |
| doi_str_mv | 10.1371/journal.pbio.1001046 |
| format | Article |
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| identifier | ISSN: 1545-7885 |
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| subjects | Aspectes genètics Base Sequence Bioinformatics Biology Chromatin Chromatin - metabolism Colleges & universities Conserved Sequence Databases, Nucleic Acid Deoxyribonucleic acid DNA DNA Methylation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Components Gene Expression Regulation Genetics Genoma humà Genome, Human Genomics Humans Internet Life Sciences Medical research Methylation Models, Genetic Physiological aspects Proteïnes de la sang Quality Control RNA, Messenger - genetics RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism |
| title | A user's guide to the encyclopedia of DNA elements (ENCODE) |
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