Mouse PRDM9 DNA-binding specificity determines sites of histone H3 lysine 4 trimethylation for initiation of meiotic recombination

Meiotic recombination generates reciprocal exchanges between homologous chromosomes (also called crossovers, COs) that are essential for proper chromosome segregation during meiosis and are a major source of genome diversity by generating new allele combinations. COs have two striking properties: th...

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Veröffentlicht in:	PLoS biology 2011-10, Vol.9 (10), p.e1001176-e1001176
Hauptverfasser:	Grey, Corinne, Barthès, Pauline, Chauveau-Le Friec, Gaëlle, Langa, Francina, Baudat, Frédéric, de Massy, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Artificial chromosomes Biology Crossing Over, Genetic Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded DNA-ligand interactions Experiments Fingers & toes Genetic diversity Genetic engineering Genetic recombination Genetics Genomes Histone-Lysine N-Methyltransferase - genetics Histones - metabolism Life Sciences Meiosis Methylation Mice Mice, Inbred C57BL Mice, Transgenic Physiological aspects Zinc finger proteins Zinc Fingers
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