ESRRA-C11orf20 is a recurrent gene fusion in serous ovarian carcinoma

Every year, ovarian cancer kills approximately 14,000 women in the United States and more than 140,000 women worldwide. Most of these deaths are caused by tumors of the serous histological type, which is rarely diagnosed before it has disseminated. By deep paired-end sequencing of mRNA from serous o...

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Veröffentlicht in:	PLoS biology 2011-09, Vol.9 (9), p.e1001156-e1001156
Hauptverfasser:	Salzman, Julia, Marinelli, Robert J, Wang, Peter L, Green, Ann E, Nielsen, Julie S, Nelson, Brad H, Drescher, Charles W, Brown, Patrick O
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Amino Acid Sequence Biology Biomarkers, Tumor - genetics Canada Carcinoma, Ovarian Epithelial Case-Control Studies Chromosome Aberrations Chromosomes, Human, Pair 11 - chemistry Chromosomes, Human, Pair 11 - genetics Cystadenocarcinoma, Serous - epidemiology Cystadenocarcinoma, Serous - genetics Cystadenocarcinoma, Serous - pathology Development and progression DNA Copy Number Variations ERRalpha Estrogen-Related Receptor Exons Female Gene expression Genes Genetic aspects Genetics Genomes Humans Medical research Medicine Molecular Sequence Data Neoplasm Staging Neoplasms, Glandular and Epithelial - epidemiology Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - pathology Oncogene Proteins, Fusion - genetics Ovarian cancer Ovarian Neoplasms - epidemiology Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Pathogenesis Physiological aspects Polymerase chain reaction Prevalence Proteins Receptors, Estrogen - genetics Risk factors RNA, Messenger Sequence Analysis, DNA Sequence Analysis, RNA United States Womens health
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