Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells

Hair cells of the mammalian cochlea are specialized for the dynamic coding of sound stimuli. The transduction of sound waves into electrical signals depends upon mechanosensitive hair bundles that project from the cell's apical surface. Each stereocilium within a hair bundle is composed of unif...

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Veröffentlicht in:	PLoS biology 2011-04, Vol.9 (4), p.e1001048
Hauptverfasser:	Zampini, Valeria, Rüttiger, Lukas, Johnson, Stuart L, Franz, Christoph, Furness, David N, Waldhaus, Jörg, Xiong, Hao, Hackney, Carole M, Holley, Matthew C, Offenhauser, Nina, Di Fiore, Pier Paolo, Knipper, Marlies, Masetto, Sergio, Marcotti, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Actin Action Potentials Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Biology Calcium - metabolism Calcium Channels - metabolism Cell Surface Extensions - metabolism Cell Surface Extensions - ultrastructure Cochlea - cytology Cochlea - growth & development Cochlea - physiology Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Deafness Deafness - genetics Ears & hearing Evoked Potentials, Auditory, Brain Stem Exocytosis Gene Deletion Hair cells (Mechanoreceptors) Hair Cells, Auditory - metabolism Hair Cells, Auditory - ultrastructure Mechanotransduction, Cellular Mice Mice, Inbred C57BL Mice, Knockout Physiological aspects Potassium Channels - metabolism Proteins Rodents
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