Plant insecticide L-canavanine repels Drosophila via the insect orphan GPCR DmX

For all animals, the taste sense is crucial to detect and avoid ingesting toxic molecules. Many toxins are synthesized by plants as a defense mechanism against insect predation. One example of such a natural toxic molecule is L-canavanine, a nonprotein amino acid found in the seeds of many legumes....

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Veröffentlicht in:	PLoS biology 2009-06, Vol.7 (6), p.e1000147
Hauptverfasser:	Mitri, Christian, Soustelle, Laurent, Framery, Bérénice, Bockaert, Joël, Parmentier, Marie-Laure, Grau, Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Avoidance Learning Avoidance Learning - drug effects Behavior Biochemistry, Molecular Biology Canavanine Canavanine - metabolism Canavanine - pharmacology Cell Biology/Neuronal Signaling Mechanisms Cell Line Cell receptors Chemoreceptor Cells Chemoreceptor Cells - cytology Chemoreceptor Cells - drug effects Chemoreceptor Cells - metabolism Control Drosophila Drosophila melanogaster Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila melanogaster - physiology Drosophila Proteins Drosophila Proteins - genetics Drosophila Proteins - metabolism Drosophila Proteins - physiology Feeding Behavior Feeding Behavior - drug effects Food G proteins Gene Expression Gene Expression - drug effects Gene Expression Profiling Genetic aspects Genetics and Genomics/Gene Function Humans Immunohistochemistry In Situ Hybridization Insecticides Insecticides - metabolism Insecticides - pharmacology Insects Life Sciences Ligands Mutation Neuroscience/Behavioral Neuroscience Neuroscience/Sensory Systems Pharmacology Plants Plants - metabolism Proteins Receptors, Cell Surface Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Cell Surface - physiology Receptors, G-Protein-Coupled Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, G-Protein-Coupled - physiology Reverse Transcriptase Polymerase Chain Reaction RNA Interference Seeds Sucrose Toxins
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