Latency antigen α-crystallin based vaccination imparts a robust protection against TB by modulating the dynamics of pulmonary cytokines

Efficient control of tuberculosis (TB) requires development of strategies that can enhance efficacy of the existing vaccine Mycobacterium bovis Bacille Calmette Guerin (BCG). To date only a few studies have explored the potential of latency-associated antigens to augment the immunogenicity of BCG. W...

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Veröffentlicht in:	PloS one 2011-04, Vol.6 (4), p.e18773-e18773
Hauptverfasser:	Dey, Bappaditya, Jain, Ruchi, Khera, Aparna, Gupta, Umesh D, Katoch, V M, Ramanathan, V D, Tyagi, Anil K
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Crystallins - administration & dosage Animals Antigens Bacillus Calmette-Guerin vaccine BCG BCG Vaccine - administration & dosage Biochemistry Biology CD4 antigen Cloning Crystal structure Crystallin Crystallinity Cytokines Cytokines - metabolism Cytometry Dendritic cells Deoxyribonucleic acid DNA DNA vaccines Flow cytometry Gene expression Guinea Pigs Immunogenicity Infections Interferon Interleukin Interleukin 1 Interleukin 10 Interleukin 12 Interleukin 2 Latency Leishmania major Leprosy Lung - metabolism Lung - pathology Lungs Lymphocytes Lymphocytes T Medicine Mice Models, Animal Mycobacterium bovis - growth & development Mycobacterium bovis - immunology Mycobacterium tuberculosis Proteins Spleen Transforming growth factor Tuberculosis Tuberculosis, Pulmonary - pathology Tuberculosis, Pulmonary - prevention & control Tumor necrosis factor-α Vaccination Vaccines
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