Innate and adaptive immune responses both contribute to pathological CD4 T cell activation in HIV-1 infected Ugandans

HIV-1 disease progression is associated with persistent immune activation. However, the nature of this association is incompletely understood. Here, we investigated immune activation in the CD4 T cell compartment of chronically HIV-1 infected individuals from Rakai, Uganda. Levels of CD4 T cell acti...

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Veröffentlicht in:	PloS one 2011-04, Vol.6 (4), p.e18779-e18779
Hauptverfasser:	Eller, Michael A, Blom, Kim G, Gonzalez, Veronica D, Eller, Leigh Anne, Naluyima, Prossy, Laeyendecker, Oliver, Quinn, Thomas C, Kiwanuka, Noah, Serwadda, David, Sewankambo, Nelson K, Tasseneetrithep, Boonrat, Wawer, Maria J, Gray, Ronald H, Marovich, Mary A, Michael, Nelson L, de Souza, Mark S, Wabwire-Mangen, Fred, Robb, Merlin L, Currier, Jeffrey R, Sandberg, Johan K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adaptive Immunity - immunology Adolescent ADP-ribosyl Cyclase 1 - metabolism Adult Analysis Antigens Antigens, CD - metabolism Antigens, Viral - immunology Antiretroviral drugs Apoptosis Regulatory Proteins - metabolism Biology CD14 antigen CD38 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD4-Positive T-Lymphocytes - virology Cell activation Cell Proliferation Chronic Disease Cytokines Deregulation Development and progression Disease Progression Drug therapy Effector cells Female Foxp3 protein Health sciences Hepatitis Histocompatibility antigen HLA HIV HIV Infections - blood HIV Infections - immunology HIV Infections - virology HIV-1 - immunology HLA-DR Antigens - metabolism Hospitals Human immunodeficiency virus Humans Immune response Immunity, Innate - immunology Immunologic Memory - immunology Immunoregulation Infections Infectious diseases Interleukin 6 Interleukin-6 - blood Lipopolysaccharide Receptors - blood Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Male Medicine Memory cells Middle Aged PD-1 protein Programmed Cell Death 1 Receptor Public health Receptors, Antigen, T-Cell, alpha-beta - metabolism Stimulation T cell receptors T cells Uganda Young Adult
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