Full-length L1CAM and not its Δ2Δ27 splice variant promotes metastasis through induction of gelatinase expression

Tumour-specific splicing is known to contribute to cancer progression. In the case of the L1 cell adhesion molecule (L1CAM), which is expressed in many human tumours and often linked to bad prognosis, alternative splicing results in a full-length form (FL-L1CAM) and a splice variant lacking exons 2...

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Veröffentlicht in:	PloS one 2011-04, Vol.6 (4), p.e18989-e18989
Hauptverfasser:	Hauser, Stephanie, Bickel, Laura, Weinspach, Dirk, Gerg, Michael, Schäfer, Michael K, Pfeifer, Marco, Hazin, John, Schelter, Florian, Weidle, Ulrich H, Ramser, Juliane, Volkmann, Juliane, Meindl, Alfons, Schmitt, Manfred, Schrötzlmair, Florian, Altevogt, Peter, Krüger, Achim
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Alternative Splicing - genetics Animals Biology Cell adhesion Cell adhesion & migration Cell adhesion molecules Cell Line, Tumor Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Disease Progression Endosomes - metabolism Enzyme Induction Exons Female Fibroblasts Fibrosarcoma - genetics Fibrosarcoma - pathology Gelatinase Gene expression Growth factors Humans Immunoglobulins Invasiveness Liver Lungs Lymphoma Lymphoma, T-Cell - genetics Lymphoma, T-Cell - pathology Matrix metalloproteinase Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 9 - biosynthesis Medicine Metalloproteinase Metastases Metastasis Mice Mutation Neoplasm Metastasis - genetics Neoplasms - enzymology Neoplasms - genetics Neoplasms - pathology Neural Cell Adhesion Molecule L1 - genetics Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Protein Transport Proteins Rodents Tumors
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