Effects of subthalamic nucleus stimulation on emotional prosody comprehension in Parkinson's disease
Although impaired decoding of emotional prosody has frequently been associated with Parkinson's disease (PD), to date only few reports have sought to explore the effect of Parkinson's treatment on disturbances of prosody decoding. In particular, little is known about how surgical treatment...
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| description | Although impaired decoding of emotional prosody has frequently been associated with Parkinson's disease (PD), to date only few reports have sought to explore the effect of Parkinson's treatment on disturbances of prosody decoding. In particular, little is known about how surgical treatment approaches such as high frequency deep brain stimulation (DBS) affect emotional speech perception in patients with PD. Accordingly, the objective of this study was to evaluate the effect of subthalamic nucleus (STN) stimulation on prosody processing.
To this end the performance of 13 PD patients on three tasks requiring the decoding of emotional speech was assessed and subsequently compared to the performance of healthy control individuals. To delineate the effect of STN-DBS, all patients were tested with stimulators turned on as well as with stimulators turned off. Results revealed that irrespective of whether assessments were made "on" or "off" stimulation, patients' performance was less accurate as compared to healthy control participants on all tasks employed in this study. However, while accuracy appeared to be unaffected by stimulator status, a facilitation of reactions specific to highly conflicting emotional stimulus material (i.e. stimulus material presenting contradicting emotional messages on a verbal and non-verbal prosodic level) was observed during "on" stimulation assessments.
In sum, presented results suggest that the processing of emotional speech is indeed modulated by STN-DBS. Observed alterations might, on the one hand, reflect a more efficient processing of highly conflicting stimulus material following DBS. However, on the other hand, given the lack of an improvement in accuracy, increased impulsivity associated with STN stimulation needs to be taken into consideration. |
| doi_str_mv | 10.1371/journal.pone.0019140 |
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To this end the performance of 13 PD patients on three tasks requiring the decoding of emotional speech was assessed and subsequently compared to the performance of healthy control individuals. To delineate the effect of STN-DBS, all patients were tested with stimulators turned on as well as with stimulators turned off. Results revealed that irrespective of whether assessments were made "on" or "off" stimulation, patients' performance was less accurate as compared to healthy control participants on all tasks employed in this study. However, while accuracy appeared to be unaffected by stimulator status, a facilitation of reactions specific to highly conflicting emotional stimulus material (i.e. stimulus material presenting contradicting emotional messages on a verbal and non-verbal prosodic level) was observed during "on" stimulation assessments.
In sum, presented results suggest that the processing of emotional speech is indeed modulated by STN-DBS. Observed alterations might, on the one hand, reflect a more efficient processing of highly conflicting stimulus material following DBS. However, on the other hand, given the lack of an improvement in accuracy, increased impulsivity associated with STN stimulation needs to be taken into consideration.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0019140</identifier><identifier>PMID: 21552518</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Assessments ; Biology ; Brain ; Brain research ; Case-Control Studies ; Comprehension - physiology ; Decoding ; Deep Brain Stimulation ; Defects ; Dementia ; Educational Status ; Electrical stimuli ; Emotions ; Emotions - physiology ; Female ; Horses ; Humans ; Impulsive behavior ; Impulsivity ; Information processing ; Linguistics ; Male ; Medical research ; Medicine ; Middle Aged ; Movement disorders ; Neurodegenerative diseases ; Neurology ; Nuclei ; Parkinson Disease - physiopathology ; Parkinson Disease - therapy ; Parkinson's disease ; Patients ; Psychiatry ; Psychotherapy ; Semantics ; Social and Behavioral Sciences ; Solitary tract nucleus ; Speech ; Speech perception ; Stimulation ; Stimulators ; Subthalamic nucleus ; Subthalamic Nucleus - physiopathology ; Surgery ; Time Factors</subject><ispartof>PloS one, 2011-04, Vol.6 (4), p.e19140-e19140</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Brück et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Brück et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-da14839b3d16809f42a20afdc9fb5621a3d91ecb8430a5698a0f6eb358019fab3</citedby><cites>FETCH-LOGICAL-c691t-da14839b3d16809f42a20afdc9fb5621a3d91ecb8430a5698a0f6eb358019fab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084266/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084266/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21552518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brück, Carolin</creatorcontrib><creatorcontrib>Wildgruber, Dirk</creatorcontrib><creatorcontrib>Kreifelts, Benjamin</creatorcontrib><creatorcontrib>Krüger, Rejko</creatorcontrib><creatorcontrib>Wächter, Tobias</creatorcontrib><title>Effects of subthalamic nucleus stimulation on emotional prosody comprehension in Parkinson's disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Although impaired decoding of emotional prosody has frequently been associated with Parkinson's disease (PD), to date only few reports have sought to explore the effect of Parkinson's treatment on disturbances of prosody decoding. In particular, little is known about how surgical treatment approaches such as high frequency deep brain stimulation (DBS) affect emotional speech perception in patients with PD. Accordingly, the objective of this study was to evaluate the effect of subthalamic nucleus (STN) stimulation on prosody processing.
To this end the performance of 13 PD patients on three tasks requiring the decoding of emotional speech was assessed and subsequently compared to the performance of healthy control individuals. To delineate the effect of STN-DBS, all patients were tested with stimulators turned on as well as with stimulators turned off. Results revealed that irrespective of whether assessments were made "on" or "off" stimulation, patients' performance was less accurate as compared to healthy control participants on all tasks employed in this study. However, while accuracy appeared to be unaffected by stimulator status, a facilitation of reactions specific to highly conflicting emotional stimulus material (i.e. stimulus material presenting contradicting emotional messages on a verbal and non-verbal prosodic level) was observed during "on" stimulation assessments.
In sum, presented results suggest that the processing of emotional speech is indeed modulated by STN-DBS. Observed alterations might, on the one hand, reflect a more efficient processing of highly conflicting stimulus material following DBS. However, on the other hand, given the lack of an improvement in accuracy, increased impulsivity associated with STN stimulation needs to be taken into consideration.</description><subject>Analysis</subject><subject>Assessments</subject><subject>Biology</subject><subject>Brain</subject><subject>Brain research</subject><subject>Case-Control Studies</subject><subject>Comprehension - physiology</subject><subject>Decoding</subject><subject>Deep Brain Stimulation</subject><subject>Defects</subject><subject>Dementia</subject><subject>Educational Status</subject><subject>Electrical stimuli</subject><subject>Emotions</subject><subject>Emotions - physiology</subject><subject>Female</subject><subject>Horses</subject><subject>Humans</subject><subject>Impulsive behavior</subject><subject>Impulsivity</subject><subject>Information processing</subject><subject>Linguistics</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Nuclei</subject><subject>Parkinson Disease - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brück, Carolin</au><au>Wildgruber, Dirk</au><au>Kreifelts, Benjamin</au><au>Krüger, Rejko</au><au>Wächter, Tobias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of subthalamic nucleus stimulation on emotional prosody comprehension in Parkinson's disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-04-28</date><risdate>2011</risdate><volume>6</volume><issue>4</issue><spage>e19140</spage><epage>e19140</epage><pages>e19140-e19140</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Although impaired decoding of emotional prosody has frequently been associated with Parkinson's disease (PD), to date only few reports have sought to explore the effect of Parkinson's treatment on disturbances of prosody decoding. In particular, little is known about how surgical treatment approaches such as high frequency deep brain stimulation (DBS) affect emotional speech perception in patients with PD. Accordingly, the objective of this study was to evaluate the effect of subthalamic nucleus (STN) stimulation on prosody processing.
To this end the performance of 13 PD patients on three tasks requiring the decoding of emotional speech was assessed and subsequently compared to the performance of healthy control individuals. To delineate the effect of STN-DBS, all patients were tested with stimulators turned on as well as with stimulators turned off. Results revealed that irrespective of whether assessments were made "on" or "off" stimulation, patients' performance was less accurate as compared to healthy control participants on all tasks employed in this study. However, while accuracy appeared to be unaffected by stimulator status, a facilitation of reactions specific to highly conflicting emotional stimulus material (i.e. stimulus material presenting contradicting emotional messages on a verbal and non-verbal prosodic level) was observed during "on" stimulation assessments.
In sum, presented results suggest that the processing of emotional speech is indeed modulated by STN-DBS. Observed alterations might, on the one hand, reflect a more efficient processing of highly conflicting stimulus material following DBS. However, on the other hand, given the lack of an improvement in accuracy, increased impulsivity associated with STN stimulation needs to be taken into consideration.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21552518</pmid><doi>10.1371/journal.pone.0019140</doi><tpages>e19140</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Analysis Assessments Biology Brain Brain research Case-Control Studies Comprehension - physiology Decoding Deep Brain Stimulation Defects Dementia Educational Status Electrical stimuli Emotions Emotions - physiology Female Horses Humans Impulsive behavior Impulsivity Information processing Linguistics Male Medical research Medicine Middle Aged Movement disorders Neurodegenerative diseases Neurology Nuclei Parkinson Disease - physiopathology Parkinson Disease - therapy Parkinson's disease Patients Psychiatry Psychotherapy Semantics Social and Behavioral Sciences Solitary tract nucleus Speech Speech perception Stimulation Stimulators Subthalamic nucleus Subthalamic Nucleus - physiopathology Surgery Time Factors |
| title | Effects of subthalamic nucleus stimulation on emotional prosody comprehension in Parkinson's disease |
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