Anti-bacterial effects of poly-N-acetyl-glucosamine nanofibers in cutaneous wound healing: requirement for Akt1

Treatment of cutaneous wounds with poly-N-acetyl-glucosamine nanofibers (sNAG) results in increased kinetics of wound closure in diabetic animal models, which is due in part to increased expression of several cytokines, growth factors, and innate immune activation. Defensins are also important for w...

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Veröffentlicht in:	PloS one 2011-04, Vol.6 (4), p.e18996
Hauptverfasser:	Lindner, Haley Buff, Zhang, Aiguo, Eldridge, Juanita, Demcheva, Marina, Tsichlis, Philip, Tsichilis, Philip, Seth, Arun, Vournakis, John, Muise-Helmericks, Robin C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - chemistry AKT1 protein Analysis Angiogenesis Animal models Animals Anti-Infective Agents - pharmacology Antibacterial agents Antibiotics Antibodies Antiinfectives and antibacterials Bacteria Bacterial effects Bacterial infections beta-Defensins - metabolism Biology Cell adhesion & migration Chlamydia Cytokines Cytokines - metabolism Defensins Diabetes mellitus Endothelial cells Endothelial Cells - cytology Endothelium Gene expression Glucosamine Growth factors Healing Health aspects Immune clearance Immune response Immune system Infections Inhibition Innate immunity Insects Keratinocytes Keratinocytes - cytology Kinetics Male Materials Science Medicine Mice Mice, Inbred C57BL Mice, Transgenic Microorganisms Microscopy Microscopy, Fluorescence - methods N-Acetylglucosamine Nanofibers Nanofibers - chemistry Neutralization Neutrophils Peptides Pharmacology Phosphorylation Proto-Oncogene Proteins c-akt - metabolism RNA, Small Interfering - metabolism Signal transduction Staphylococcus aureus Staphylococcus aureus infections Wound care Wound Healing Wound infection
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