Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol

Mammalian target of rapamycin (mTOR)/S6K1 signalling emerges as a critical regulator of aging. Yet, a role of mTOR/S6K1 in aging-associated vascular endothelial dysfunction remains unknown. In this study, we investigated the role of S6K1 in aging-associated endothelial dysfunction and effects of the...

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Veröffentlicht in:	PloS one 2011-04, Vol.6 (4), p.e19237
Hauptverfasser:	Rajapakse, Angana G, Yepuri, Gautham, Carvas, João M, Stein, Sokrates, Matter, Christian M, Scerri, Isabelle, Ruffieux, Jean, Montani, Jean-Pierre, Ming, Xiu-Fen, Yang, Zhihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Aging Aging (artificial) Aging - genetics Aging - metabolism Animals Antioxidants Aorta - drug effects Aorta - metabolism Apoptosis Biological activity Cardiology Cell growth Cells, Cultured Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium Gene expression Heart Humans Immunoblotting In Vitro Techniques Inhibition Kinases Male Medicine Middle age Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Older people Overexpression Oxidative stress Oxidative Stress - drug effects Oxidative Stress - genetics Phosphorylation Physiology Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rapamycin Rats Rats, Inbred WKY Resveratrol Ribosomal Protein S6 Kinases - genetics Ribosomal Protein S6 Kinases - metabolism RNA, Small Interfering Rodents Senescence Signaling Stilbenes - pharmacology Superoxide Superoxides Superoxides - metabolism TOR protein Transcription factors Uterine cancer Vascular diseases
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