Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice

Strong evidence supports a protective role of the cannabinoid receptor 2 (CB(2)) in inflammation and atherosclerosis. However, direct proof of its involvement in lesion formation is lacking. Therefore, the present study aimed to characterize the role of the CB(2) receptor in Murine atherogenesis. Lo...

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Veröffentlicht in:	PloS one 2011-04, Vol.6 (4), p.e19405
Hauptverfasser:	Willecke, Florian, Zeschky, Katharina, Ortiz Rodriguez, Alexandra, Colberg, Christian, Auwärter, Volker, Kneisel, Stefan, Hutter, Melanie, Lozhkin, Andrey, Hoppe, Natalie, Wolf, Dennis, von zur Mühlen, Constantin, Moser, Martin, Hilgendorf, Ingo, Bode, Christoph, Zirlik, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Apoptosis Arches Arteriosclerosis Atherogenesis Atherosclerosis Atherosclerosis - metabolism Atherosclerosis - pathology Biology Cannabinoid CB2 receptors Cannabinoids - pharmacokinetics Cannabinoids - pharmacology Cardiology Cell activation Cell adhesion Cell Survival - drug effects Cholesterol Clonal deletion Collagen Cytokines Cytokines - metabolism Disease Disease Models, Animal Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Feeding Behavior - drug effects High cholesterol diet Inflammation Inflammation - pathology Intercellular Adhesion Molecule-1 - metabolism Ischemia Lesions Ligands Lipids Lipoprotein (low density) receptors Low density lipoprotein receptors Lymphocytes Lymphocytes T Macrophages Mass Spectrometry Medicine Mice Mice, Inbred C57BL Monocytes - drug effects Monocytes - pathology Neutrophils Pathogenesis Peritonitis Pharmacology Receptor density Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - deficiency Receptor, Cannabinoid, CB2 - metabolism Recruitment Rodents Signal transduction Signal Transduction - drug effects Signaling Smooth muscle T cells Toxicology
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