YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion

Genomic rearrangements involving the ETS family of transcription factors occur in 40-70% of prostate cancer cases. ERG and ETV1 are the most common ETS members observed in these genetic alterations. The high prevalence of these rearrangements and their biological significance represents a novel ther...

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Veröffentlicht in:	PloS one 2011-04, Vol.6 (4), p.e19343-e19343
Hauptverfasser:	Rahim, Said, Beauchamp, Elspeth M, Kong, Yali, Brown, Milton L, Toretsky, Jeffrey A, Üren, Aykut
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Animals Antineoplastic Agents - pharmacology Apoptosis Assaying Biological activity Biology Blotting, Western Cancer Cell Line, Tumor Cercopithecus aethiops Chromatin Immunoprecipitation COS Cells DNA binding proteins DNA-Binding Proteins - metabolism Drug Screening Assays, Antitumor - methods Ewing's sarcoma Ewings sarcoma EWS protein Fibroblasts Fusion protein Gene expression Humans Indoles - pharmacology Invasiveness Kinetics Male Medicine Metastases Metastasis Motility Neoplasm Invasiveness Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Proteins RNA Sarcoma siRNA Therapeutic applications Trans-Activators - metabolism Transcription factors Transcription Factors - metabolism Transcriptional Regulator ERG
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