Enhanced collateral growth by double transplantation of gene-nucleofected fibroblasts in ischemic hindlimb of rats

Induction of neovascularization by releasing therapeutic growth factors is a promising application of cell-based gene therapy to treat ischemia-related problems. In the present study, we have developed a new strategy based on nucleofection with alternative solution and cuvette to promote collateral...

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Veröffentlicht in:	PloS one 2011-04, Vol.6 (4), p.e19192-e19192
Hauptverfasser:	Zhang, Ziyang, Slobodianski, Alex, Ito, Wulf D, Arnold, Astrid, Nehlsen, Jessica, Weng, Shaoxiang, Lund, Natalie, Liu, Jihong, Egaña, José-Tomás, Lohmeyer, Jörn A, Müller, Daniel F, Machens, Hans-Günther
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Anticoagulants Biotechnology Blood vessels Cells, Cultured Child development Clinical trials Collateral Circulation - genetics Collateral Circulation - physiology Computed tomography Deoxyribonucleic acid DNA Drug dosages Efficiency Endothelial growth factors Feasibility studies Femoral artery Femur Fibroblast growth factor 2 Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - metabolism Fibroblast growth factors Fibroblasts Fibroblasts - metabolism Fibroblasts - transplantation Gene therapy Genes Growth Growth factors Hand surgery Health aspects Hindlimb - pathology Hospitals Hydrogels Ischemia Ischemia - therapy Male Medicine Microspheres Neovascularization Neovascularization, Physiologic - genetics Neovascularization, Physiologic - physiology Organs Perfusion Plasmids Plasmids - genetics Plastic surgery Proteins Rats Rodents Skin Studies Transfection Transplantation Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascularization Vectors (Biology)
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