Differential proteomic analysis of platelets suggested possible signal cascades network in platelets treated with salvianolic acid B

Salvianolic acid B (SB) is an active component isolated from Danshen, a traditional Chinese medicine widely used for the treatment of cardiovascular disorders. Previous study suggested that SB might inhibit adhesion as well as aggregation of platelets by a mechanism involving the integrin α2β1. But,...

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Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e14692-e14692
Hauptverfasser:	Ma, Chao, Yao, Yan, Yue, Qing-Xi, Zhou, Xin-Wen, Yang, Peng-Yuan, Wu, Wan-Ying, Guan, Shu-Hong, Jiang, Bao-Hong, Yang, Min, Liu, Xuan, Guo, De-An
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Analysis Animals Antibodies Automation Benzofurans - metabolism Benzofurans - pharmacology Binding Bioassays Biological assays Biotechnology/Protein Chemistry and Proteomics Blood platelets Blood Platelets - chemistry Blood Platelets - drug effects Blood Platelets - metabolism Cardiovascular disease Cardiovascular Disorders/Cardiovascular Pharmacology Cascades Chinese medicine Collagen Cytoskeleton Cytotoxicity Drug dosages Dynein Electron microscopy Heat shock Heat shock proteins Herbal medicine Hsp70 protein Integrin alpha2beta1 - metabolism Integrins Intracellular Intracellular levels Kinases Male Medical research Metabolic Networks and Pathways - drug effects Microscopy Models, Biological Modernization Oxygen Peptides Peroxiredoxin Pharmacology Platelet Adhesiveness - drug effects Platelet Aggregation - drug effects Platelets Pretreatment Proteins Proteins - analysis Proteins - metabolism Proteome - analysis Proteome - drug effects Proteomics - methods Rats Rats, Sprague-Dawley Reactive oxygen species Traditional Chinese medicine Trends Two dimensional analysis Western blotting
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