Assessing protein immunogenicity with a dendritic cell line-derived endolysosomal degradome

The growing number of novel candidate molecules for the treatment of allergic diseases imposed a dramatic increase in the demand for animal experiments to select immunogenic vaccines, a pre-requisite for efficacy. Because no in vitro methods to predict the immunogenicity of a protein are currently a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e17278-e17278
Hauptverfasser:	Egger, Matthias, Jürets, Alexander, Wallner, Michael, Briza, Peter, Ruzek, Silke, Hainzl, Stefan, Pichler, Ulrike, Kitzmüller, Claudia, Bohle, Barbara, Huber, Christian G, Ferreira, Fátima
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic diseases Allergies Allergy Animal experimentation Animal research Animals Antibody Formation - physiology Antigen presentation Antigens Assaying Bet v 1 antigen Biology Bone composition Bone marrow Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Cell Line Degradation Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic structure Experiments Gel electrophoresis Genes, p53 Humans Hypersensitivity Immune response Immunogenicity Immunology Immunotherapy In vitro methods and tests Kinetics Laboratories Ligands Lymphocytes Lymphocytes T Lysosomes - immunology Lysosomes - metabolism Mass spectrometry Mass spectroscopy Medical research Medical treatment Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Molecular biology Peptides Priming Proteases Protein composition Protein Processing, Post-Translational - immunology Protein Processing, Post-Translational - physiology Proteins Proteins - immunology Proteins - metabolism Proteolysis Ribonuclease T cell receptors T cells Vaccine development Vaccines Vaccines - biosynthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!