Peptidoglycan crosslinking relaxation plays an important role in Staphylococcus aureus WalKR-dependent cell viability

The WalKR two-component system is essential for viability of Staphylococcus aureus, a major pathogen. We have shown that WalKR acts as the master controller of peptidoglycan metabolism, yet none of the identified regulon genes explain its requirement for cell viability. Transmission electron microgr...

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Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e17054-e17054
Hauptverfasser:	Delaune, Aurelia, Poupel, Olivier, Mallet, Adeline, Coic, Yves-Marie, Msadek, Tarek, Dubrac, Sarah
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Amidase Bacillus subtilis Bacteria Bacterial Proteins Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Proteins - physiology Biology Carbohydrate Metabolism Carbohydrate Metabolism - genetics Carbohydrate Sequence Carbohydrate Sequence - physiology Cell division Cell Wall Cell Wall - enzymology Cell Wall - metabolism Cell walls Cloning Crosslinking E coli Electron micrographs Endopeptidases Endopeptidases - metabolism Endopeptidases - physiology Escherichia coli Gene expression Gene Expression Regulation, Bacterial Gene Expression Regulation, Bacterial - physiology Gene Expression Regulation, Enzymologic Gene Expression Regulation, Enzymologic - physiology Genes Genomics Glycyl endopeptidase Gram-positive bacteria Hydrolases Hydrolases - genetics Hydrolases - metabolism Hydrolysis Laboratories Life Sciences Metabolism Microbial Viability Microbial Viability - genetics Microbiology and Parasitology Microscopy Models, Biological Morphology Multiprotein Complexes Multiprotein Complexes - metabolism Multiprotein Complexes - physiology Mutagenesis Organisms, Genetically Modified Pathogens Pentaglycine Peptidoglycan Peptidoglycan - chemistry Peptidoglycan - metabolism Peptidoglycans Photomicrographs Physiological aspects Polymer crosslinking Polymerase chain reaction Protein Multimerization Protein Multimerization - physiology Regulation RNA polymerase Septum Signal transduction Staphylococcus aureus Staphylococcus aureus - genetics Staphylococcus aureus - metabolism Staphylococcus aureus - physiology Streptococcus infections Streptococcus salivarius Stress response Thickening
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