Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5)

Parkinson's disease (PD) is a common neurodegenerative condition in which abnormalities in protein homeostasis, or proteostasis, may lead to accumulation of the protein α-synuclein (α-syn). Mutations within or multiplications of the gene encoding α-syn are known to cause genetic forms of PD and...

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Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e14695
Hauptverfasser:	Kalia, Lorraine V, Kalia, Suneil K, Chau, Hien, Lozano, Andres M, Hyman, Bradley T, McLean, Pamela J
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adaptor Proteins, Signal Transducing Aged Aged, 80 and over alpha-Synuclein - metabolism Alzheimer's disease Amino acids Bcl-2 protein Biochemistry/Protein Chemistry Brain Brain research Carrier Proteins - genetics Carrier Proteins - metabolism Carrier Proteins - physiology Catalytic Domain - genetics Catalytic Domain - physiology Cell death Cell division Cell growth Complementation Drosophila Female Gaussia princeps Health care networks Homeostasis Hospitals Hsp70 protein Humans Insects Lewy bodies Localization Luciferases - genetics Luciferases - metabolism Medical schools Movement disorders Musculoskeletal system Mutation Neurodegenerative diseases Neurological Disorders/Movement Disorders Neurology Neuropathology Neuroscience/Neurobiology of Disease and Regeneration Neuroscience/Neuronal Signaling Mechanisms Neurosciences Neurosurgery Neurotoxicity Oligomerization Oligomers Parkinson's disease Protein Binding - genetics Protein Binding - physiology Protein Multimerization Protein Processing, Post-Translational - genetics Protein Processing, Post-Translational - physiology Protein Structure, Tertiary - genetics Protein Structure, Tertiary - physiology Proteins Quality control Risk analysis Risk factors Rodents Synuclein Transfection Tumor Cells, Cultured Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitin-Protein Ligases - physiology Ubiquitination
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