Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages

Sialoadhesin is exclusively expressed on specific subpopulations of macrophages. Since sialoadhesin-positive macrophages are involved in inflammatory autoimmune diseases, such as multiple sclerosis, and potentially in the generation of immune responses, targeted delivery of drugs, toxins or antigens...

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Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e16827
Hauptverfasser:	Delputte, Peter L, Van Gorp, Hanne, Favoreel, Herman W, Hoebeke, Inge, Delrue, Iris, Dewerchin, Hannah, Verdonck, Frank, Verhasselt, Bruno, Cox, Eric, Nauwynck, Hans J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Albumin Animals Antibodies Antigens Antigens - metabolism Apoptosis Autoimmune diseases Biology Bone marrow Carrier Proteins - metabolism Carrier Proteins - physiology Cell Survival - drug effects Cells, Cultured Chemical inhibitors Clathrin Dose-Response Relationship, Drug Drug delivery Drug delivery systems Drugs E coli Endocytosis Endocytosis - physiology Endosomes Escherichia coli Glycoproteins Health aspects Hogs Immune response Immunization Immunoconjugates Immunofluorescence Immunoglobulins Immunologic factors Immunology Immunosuppressive agents Immunotoxins Immunotoxins - pharmacology Internalization Lipids Lysosomes Macrophages Macrophages, Alveolar - drug effects Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Medicine Membrane Glycoproteins - metabolism Membrane Glycoproteins - physiology Multiple sclerosis Parasitology Pathogens Phosphorylation Protein Transport - physiology Receptors, Cell Surface - metabolism Receptors, Immunologic - metabolism Receptors, Immunologic - physiology Sialic Acid Binding Ig-like Lectin 1 Signal transduction Subpopulations Swine Toxins Toxins, Biological - metabolism Transport Vesicles - metabolism Veterinary medicine Virology
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