Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway

Human VRK1 induces a stabilization and accumulation of p53 by specific phosphorylation in Thr18. This p53 accumulation is reversed by its downregulation mediated by Hdm2, requiring a dephosphorylated p53 and therefore also needs the removal of VRK1 as stabilizer. This process requires export of VRK1...

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Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e17320
Hauptverfasser:	Valbuena, Alberto, Castro-Obregón, Susana, Lazo, Pedro A
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Antineoplastic Agents - pharmacology Apoptosis Autophagy - drug effects Autophagy - genetics Autophagy - physiology Autophagy - radiation effects Biology Cell cycle Cell Cycle - drug effects Cell Cycle - genetics Cell Cycle - physiology Cell Cycle - radiation effects Cell death Cells, Cultured Computer memory Cytosol Damage accumulation Degradation Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects DNA Damage - genetics DNA Damage - physiology DNA Damage - radiation effects DNA repair Down-Regulation Doxorubicin Doxorubicin - pharmacology Etoposide Etoposide - pharmacology Gene expression Gene Expression Regulation - drug effects Gene Expression Regulation - radiation effects Gene Knockdown Techniques Humans Infrared Rays Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Ionizing radiation Kinases Leptomycin B Lysosomes Membrane Proteins Models, Biological Mutants Ovarian cancer p53 Protein Phosphorylation Proteasomes Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proteins - antagonists & inhibitors Proteins - genetics Proteins - physiology RNA, Small Interfering - pharmacology Saccharomyces cerevisiae Signal Transduction - drug effects Signal Transduction - genetics Signal Transduction - physiology Signal Transduction - radiation effects Skin cancer Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - physiology Ultraviolet radiation Ultraviolet Rays
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