Androgen-induced cell migration: role of androgen receptor/filamin A association

Androgen receptor (AR) controls male morphogenesis, gametogenesis and prostate growth as well as development of prostate cancer. These findings support a role for AR in cell migration and invasiveness. However, the molecular mechanism involved in AR-mediated cell migration still remains elusive. Mou...

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Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e17218
Hauptverfasser:	Castoria, Gabriella, D'Amato, Loredana, Ciociola, Alessandra, Giovannelli, Pia, Giraldi, Tiziana, Sepe, Leandra, Paolella, Giovanni, Barone, Maria Vittoria, Migliaccio, Antimo, Auricchio, Ferdinando
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Activation Analysis Androgen receptors Androgens Androgens - pharmacology Animals Biology Cancer Cancer metastasis Carcinoma - metabolism Carcinoma - pathology Cell adhesion & migration Cell migration Cell Movement - drug effects Cells, Cultured Chlorocebus aethiops Contractile Proteins - metabolism Contractile Proteins - physiology COS Cells Cytoskeleton Deoxyribonucleic acid Development and progression DNA Fibroblasts Fibrosarcoma Filamins Focal adhesion kinase Gametogenesis Genotype & phenotype Humans Integrin beta1 - metabolism Integrin beta1 - physiology Integrins Invasiveness Kinases Leukocyte migration Localization Male Medicine Metastases Metribolone - pharmacology Mice Microfilament Proteins - metabolism Microfilament Proteins - physiology Morphogenesis Motility Mutation Neoplasm Metastasis NIH 3T3 Cells Paxillin Phosphorylation Physiological aspects Physiology Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Protein Binding - drug effects Protein Binding - physiology Proteins Receptors, Androgen - metabolism Receptors, Androgen - physiology Sarcoma Signaling Transcription Tyrosine
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