Limited transplantation of antigen-expressing hematopoietic stem cells induces long-lasting cytotoxic T cell responses

Harnessing the ability of cytotoxic T lymphocytes (CTLs) to recognize and eradicate tumor or pathogen-infected cells is a critical goal of modern immune-based therapies. Although multiple immunization strategies efficiently induce high levels of antigen-specific CTLs, the initial increase is typical...

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Veröffentlicht in:	PloS one 2011-02, Vol.6 (2), p.e16897-e16897
Hauptverfasser:	Denning, Warren L, Xu, Jun, Guo, Siqi, Klug, Christopher A, Hel, Zdenek
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Animals Antigen presentation Antigens Antigens - metabolism Apoptosis Autoimmune diseases B cells Biology Bone marrow Cancer CD8 antigen CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - transplantation Cells, Cultured Chickens - genetics Clinical trials Communicable Diseases - immunology Communicable Diseases - therapy Conditioning Contraction Cytotoxicity Data processing Dendritic cells Gene therapy Genetic engineering Genetic Therapy - methods Health aspects Hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - metabolism HIV Human immunodeficiency virus Immunization Immunologic Memory - genetics Immunologic Memory - physiology Immunological memory Immunological tolerance Immunotherapy Immunotherapy, Adoptive - methods Infections Infectious diseases Lymphocytes Lymphocytes T Medicine Memory cells Mice Mice, Inbred C57BL Mice, Transgenic Neoplasms - immunology Neoplasms - therapy Ovalbumin - genetics Ovalbumin - metabolism Pathology Rodents Stem cell transplantation Stem cells T cell receptors T cells T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Time Factors Transplantation Vaccines Vectors (Biology) Viral infections
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