De novo polymerase activity and oligomerization of hepatitis C virus RNA-dependent RNA-polymerases from genotypes 1 to 5

Hepatitis C virus (HCV) shows a great geographical diversity reflected in the high number of circulating genotypes and subtypes. The response to HCV treatment is genotype specific, with the predominant genotype 1 showing the lowest rate of sustained virological response. Virally encoded enzymes are...

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Veröffentlicht in:	PloS one 2011-04, Vol.6 (4), p.e18515-e18515
Hauptverfasser:	Clemente-Casares, Pilar, López-Jiménez, Alberto J, Bellón-Echeverría, Itxaso, Encinar, José Antonio, Martínez-Alfaro, Elisa, Pérez-Flores, Ricardo, Mas, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biology Cloning Coding Cooperativity Crystal structure Deoxyribonucleic acid DNA DNA polymerase Docking Electrophoretic Mobility Shift Assay Fluorescence Resonance Energy Transfer Genetic aspects Genomes Genotype Genotype & phenotype Genotypes Hepacivirus - enzymology Hepatitis Hepatitis C Hepatitis C virus Infectious diseases Mathematical analysis Medicine Molecular Sequence Data Mutants Mutation Oligomerization Oligomers Phylogeny Plasmids Polymerase Chain Reaction Proteases Proteins Residues Ribonucleic acid RNA RNA polymerase RNA viruses RNA-Dependent RNA Polymerase - chemistry RNA-Dependent RNA Polymerase - classification RNA-Dependent RNA Polymerase - genetics RNA-Dependent RNA Polymerase - metabolism RNA-directed RNA polymerase Sequence Homology, Amino Acid Viability Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - classification Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Viruses
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