Network-guided analysis of genes with altered somatic copy number and gene expression reveals pathways commonly perturbed in metastatic melanoma

Cancer genomes frequently contain somatic copy number alterations (SCNA) that can significantly perturb the expression level of affected genes and thus disrupt pathways controlling normal growth. In melanoma, many studies have focussed on the copy number and gene expression levels of the BRAF, PTEN...

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Veröffentlicht in:	PloS one 2011-04, Vol.6 (4), p.e18369-e18369
Hauptverfasser:	Valsesia, Armand, Rimoldi, Donata, Martinet, Danielle, Ibberson, Mark, Benaglio, Paola, Quadroni, Manfredo, Waridel, Patrice, Gaillard, Muriel, Pidoux, Mireille, Rapin, Blandine, Rivolta, Carlo, Xenarios, Ioannis, Simpson, Andrew J G, Antonarakis, Stylianos E, Beckmann, Jacques S, Jongeneel, C Victor, Iseli, Christian, Stevenson, Brian J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Analysis Angiogenesis Bioinformatics Biology Cadherins Cancer Cancer genetics Cancer metastasis Cell Line, Tumor Chromosomes Comparative Genomic Hybridization Copy number Cytogenetics Databases, Genetic Datasets DNA Copy Number Variations - genetics Encyclopedias Experiments Gene expression Gene Expression Regulation, Neoplastic Gene Regulatory Networks - genetics Genes Genes, Neoplasm - genetics Genetic aspects Genetic research Genetics Genomes Genomics Humans In Situ Hybridization, Fluorescence Karyotyping Medical research Medicine Melanoma Melanoma - genetics Melanoma - pathology Metastases Metastasis Microphthalmia-associated transcription factor Neoplasm Metastasis Parameter identification Polymorphism, Single Nucleotide - genetics Prostate cancer Proteins Proteomics Proto-Oncogene Proteins c-mdm2 - genetics Provenance PTEN protein Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism Signal transduction Signal Transduction - genetics Signaling Single-nucleotide polymorphism Tumorigenesis Wnt protein
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