Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria

Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated as potential alternative treatments. One plausible antimicrobial alternative could be th...

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Veröffentlicht in:	PloS one 2011-04, Vol.6 (4), p.e18127
Hauptverfasser:	Fiamegos, Yiannis C, Kastritis, Panagiotis L, Exarchou, Vassiliki, Han, Haley, Bonvin, Alexandre M J J, Vervoort, Jacques, Lewis, Kim, Hamblin, Michael R, Tegos, George P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids analogs Analysis Animals Anti-Bacterial Agents - pharmacology Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Anti-Infective Agents - toxicity antibiotic-activity Antibiotics Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Artemisia absinthium Artemisia absinthium - chemistry ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - metabolism Bacteria Berberine Berberine - metabolism Berberis Bioassays Biofilms Biofilms - drug effects Biological products Biology Caffeoylquinic acid Chemical compounds Chemistry Chlorogenic acid chlorogenic acids Chromatography Clinical isolates Columns (structural) Cytotoxicity derivatives Dermatology Docking Drug Resistance, Multiple - drug effects Drug Synergism Efflux Enterococcus faecalis Glycoproteins Gram-positive bacteria Gram-Positive Bacteria - drug effects Gram-Positive Bacteria - metabolism Gram-Positive Bacteria - physiology Health aspects Health sciences Hemolysis - drug effects Hospitals Humans Infection Infection control Inhibitors Liquid chromatography Magnetic permeability Magnetic resonance Magnetic resonance spectroscopy Mass spectrometry Mass spectroscopy Medicine Microbial drug resistance Microorganisms Models, Molecular Molecular modelling Multidrug resistance N.M.R Natural products NMR nora Nuclear magnetic resonance Nuclear magnetic resonance spectroscopy Pathogens phenolic compounds Phenols Plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - toxicity Potentiation protein Protein Conformation Proteins Pseudomonas fluorescens Purification Quinic Acid - analogs & derivatives Quinic Acid - chemistry Quinic Acid - pharmacology Quinic Acid - toxicity Spectroscopy Staphylococcus aureus Substrates transporter
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